加拿大不列颠哥伦比亚大学博士后职位招聘–基因调节疾病个性化医学

At UBC, we believe that attracting and sustaining a diverse workforce is key to the successful pursuit of excellence in research, innovation, and learning for all faculty, staff and students. Our commitment to employment equity helps achieve inclusion and fairness, brings rich diversity to UBC as a workplace, and creates the necessary conditions for a rewarding career. 

The School of Biomedical Engineering (SBME) at the University of British Columbia (UBC), Vancouver campus invites applications for two full time Postdoctoral Research Fellow positions in the de Boer lab (https://deboer.bme.ubc.ca/). The initial appointment will be for one year with the possibility of extension subject to work performance and funding availability.

The Boer lab is a mixed computational/experimental group studying gene regulation using synthetic genomics and machine learning with the aim of having a sufficiently detailed understanding of gene expression that we can design personalized therapeutics to prevent and treat disease.

The Faculties of Medicine and Applied Science have partnered to create the SBME, a new flagship entity at UBC, and a top strategic priority for the University and both Faculties. The SBME is a nucleus for education and training, research, and innovation in biomedical engineering, creating new knowledge, new academic and training programs, and fostering translation and innovation. UBC SBME distinguishes itself by deep training in biology, and engineering science and design, enabling SBME researchers to address the most pressing biomedical challenges of the day. Our SBME faculty conduct research that advances our fundamental understanding of human biology, and yields technologies and therapies that advance our health and wellbeing.

Organizational Status

Individuals will report to Dr. Carl de Boer.

Responsibilities

The responsibilities of this position will depend on the strengths of the incumbent, but may include:

• Optimizing, performing, and analyzing high-throughput chemical screens.
• Developing genomics technologies including, reporter assays, DNA synthesis, genome engineering.
• Reconstructing gene regulatory networks and performing GRN inference.
• Single-cell RNA-seq, perturb-seq, and/or other transcriptomic analysis.
• Next generation sequencing and bioinformatics analysis.
• Machine learning/AI; making, evaluating, and interpreting models.
• Analyzing genetics data (e.g. GWAS, eQTLs), including predicting variant effects, stratifying patients, identifying desired patients for recall.
• Designing, synthesizing, and testing regulatory or protein coding DNA sequences.
• Analyzing data and presenting the data in reports, publications, and presentations at local and international conferences.
• Training and mentoring lab personnel, including supervising a wet lab technician.
• Human pluripotent stem cell culture including maintenance, expansion, and characterization.
• Cell differentiation and culture.
• Genetic engineering of mammalian cells.
• Helping to enhance our collaborative and interdisciplinary research environment.
• Contributing to cutting-edge knowledge in the scientific community.
• Designing and performing experiments, analyzing results, and presenting findings.
• Preparing and assisting with grant applications, publications and with fulfilling regulatory requirements (animal ethics, biosafety etc.)
• Applying for fellowships, as applicable and mutually agreed upon with your supervisor.

Qualifications

• Candidates must hold a PhD, obtained within the last 5 year or MD, obtained within the last 10 years.
• Candidates should have a strong research background, as demonstrated by past publications, accomplishments, and references.
• Candidates with strong background in either computational or experimental biology (or both) will be considered.
• The successful candidate will be a passionate, self-driven, independent thinker with excellent organizational, oral and written communication, and interpersonal skills, and a strong work ethic.
• Preference will be given to candidates who have skills in any of the following areas:
  • High-throughput chemical screening and hit-to-lead optimization
  • Genetics/GWAS/eQTL analysis
  • Massive parallel reporter assays
  • DNA synthesis technology
  • Machine learning for genomics
  • Single cell omics (e.g. perturb-seq)
  • Genomics technology development
  • Gene regulatory network reconstruction
  • Functional genomics technologies (e.g. fiber-seq, CUT&Tag, ATAC-seq)

Supervision received

The incumbent will receive supervision directly from Dr. de Boer.

Supervision given

The ideal incumbent will have the opportunity to be the primary supervisor of a technician who will be performing the experimental procedures related to this project. They may also be required to supervise other trainees involved in the research program.

Start date and stipend

The anticipated start date for this position is Oct 1, 2024 or upon a date to be mutually agreed. Salary will be commensurate with qualifications and experience, and may range from $60,000-$80,000 per year.

How to Apply

Candidates should provide a CV, names and contact information of 3 references, and a cover letter describing past achievements and future research interests. Please submit your applications directly to Dr. Carl de Boer ([Please click the Apply button for the link or address]), whom you can also contact if you have questions. Review of applications will begin after this job posting closes, and continue until the position is filled.

We respectfully acknowledge that the UBC Vancouver campus is located on the traditional, ancestral, unceded territory of the xʷməθkʷəy̓əm (Musqueam) people.

Equity and diversity are essential to academic excellence. An open and diverse community fosters the inclusion of voices that have been underrepresented or discouraged. We encourage applications from members of groups that have been marginalized on any grounds enumerated under the B.C. Human Rights Code, including sex, sexual orientation, gender identity or expression, racialization, disability, political belief, religion, marital or family status, age, and/or status as a First Nation, Metis, Inuit, or Indigenous person. 

All qualified candidates are encouraged to apply; however, Canadians and permanent residents of Canada will be given priority.