德国弗赖堡大学博士后职位招聘–物理、化学、生物物理学方向

As a part of the collaborative research cluster “nEOdiag” funded by the Carl-Zeiss-Stiftung 
(https://www.carl-zeiss-stiftung.de/themen-projekte/uebersicht-projekte/detail/nanoporen-basierte-elektrisch-optische-proteindiagnostik-neodiag), the University of Freiburg (https://www.uni-freiburg.de) offers a postdoc position (E13 TV-L) in a fixed-term contract for a minimum of two years to work on the project »Development of marker-free electrical-optical sensing based on biological nanopores«.
Biological and solid state nanopores play an increasing role in molecular diagnostics.

The goal of this project is to establish their use for the identification of peptides and their post-translational modifications that are found in a variety of pathological conditions, including cancer, cardiovascular, neurodegenerative, and infectious diseases. Simultaneous observation of the electrical current through a single nanopore, and the optical signal from a dye molecule inside the pore will provide characteristic information of the peptide bound in the pore. While electrical readout of the nanopore has been established, the optical readout of the fluorescence marker on a single-molecule level is the focus of this project.

Responsibilities

The responsibilities of the successful applicants will include:

• Design and construction of a combined electrophysiology/microscopy setup
• Wet lab work for fabrication of nanopores in lipid bilayers
• Molecular biology and biochemistry to generate chimeric and mutant pore proteins
• Experiments and data analysis
• Comprehensive presentation of results in group meetings and at conferences
• Preparation of manuscripts

Qualification

What we are looking for:

• Talented and highly motivated candidates with a PhD in physics, chemistry, biophysics or equivalent skills
• Strong interest in microscopy, electrophysiology, instrument design and nanopore physics
• Experience in electrophysiology and/or microscopy
• Background in programming, molecular biology, and biochemistry
• Ability to work independently and in a team

Interested?

Applications should include:

• Curriculum vitae with name, address, degree(s), research experience, educational and employment history, awards and publication list
• Transcript(s) of grades
• Motivation letter
• Name and e-mail addresses of at least two academic references

The starting date is as soon as possible.

Contact
Please send your full application to:
Dr. Maximilian Ulbrich
max.ulbrich@bioss.uni-freiburg.de