瑞典哥德堡大学博士后职位招聘–怀孕流行病学/基因组学方向

Our research group is located at the University of Gothenburg in Sweden and the Norwegian Institute of Public Health (Oslo). We investigate genetic and environmental factors affecting human gestational age at birth. We work with unique genomic data containing thousands of family trios from Norway, coupled with a rich collection of pregnancy-related medical variables and an extensive set of validated environmental exposures, and a large medical birth register with more than 4 million pregnancies from Sweden. The Perinatal laboratory and research group is led by Professor Bo Jacobsson.

Research project 1

There are substantial differences in preterm birth rates across high-income countries. In a recent international project, we assessed the contributions of known risk factors to preterm delivery rates; they only explain a small proportion of the overall variation. In a follow-up study, we found a considerable variation within Sweden (three times difference), as large as that between countries.

This project, will explore the geographical and temporal differences in pregnancy and child outcomes in Sweden and identify possible individual and contextual causes. Our main aim is to understand better how sociodemographic, environmental and contextual factors affect pregnancy and child outcomes in different parts of Sweden. Our focus will be preterm delivery, pregnancy complications, perinatal mortality, and neonatal morbidity, utilizing the Swedish Medical Birth Registry, Multigenerational Registry, different Quality Registries, and data from Statistics Sweden (DeSO areas among others).

Research project 2

Preterm delivery and the duration of gestation are heritable traits. Our group has recently published the largest GWAS meta-analysis of gestational duration and preterm birth to date. The postdoc fellow will contribute to ongoing efforts in this field (GWAS, meta-analyses, gene-environment interactions, etc) and to dive deeper into the known genetic variants affecting the duration of gestation and preterm delivery. We expect to expand the analyses conducted in our previous work to diverse ancestries, and to sub-phenotypes of preterm delivery.

The postdoc fellow will use world-unique data from the Mother, Father and Child Cohort study, which includes genotype and phenotype data from from over 40,000 parent-offspring trios, and data from ALSPAC (~6,000 mother-child pairs).

Duties

The main task is to conduct high-quality research in perinatal medical research in one of the specific research projects. There will be great opportunities to expand the project’s focus within the framework of the specified project and the postdoctoral fellow’s interests. The applicant is expected to be able to contribute to both projects to some extent.

The tasks include, among other things, data collection, quality control and analysis, dissemination of results, and supervision of master’s students and doctoral students. Furthermore, the postdoctoral fellow is expected to contribute to publications. The work task also include all types of administrative work such as writing scientific reports and project proposals, acquiring ethical approvals, as well as authoring and co-authoring research manuscripts, including the submission to the journal process and other tasks. This applies to the entire group’s needs