丹麦哥本哈根大学博士后职位招聘–生物化学、生理学、新陈代谢方向
Faculty of Health and Medical Sciences
University of Copenhagen
We are looking for a highly motivated and dynamic postdoc who is experienced in biochemical and metabolic research for a fully-funded 2 years and 9 months position to commence 1 April 2024, or as soon as possible thereafter.
This position will use rodent and cell-based experiments to answer questions about how different lipid metabolites affect metabolic disease, including fatty liver disease/NASH and insulin resistance.
The project will be carried out at the Department of Biomedical Sciences, UCPH. Information on the department can be found at: https://bmi.ku.dk/english/
Our research
The position will be based in Trisha Grevengoed’s group. The Grevengoed group is unravelling the biological roles of a novel class of amphiphilic lipids known as N-acyl taurines (NATs) through the use of interdisciplinary techniques, including mass spectrometry-based metabolomics and in vivo and in vitro analysis. So far, we have established that NATs are biliary lipids increased by omega-3 fatty acid supplementation, and thus may be important mediators of the beneficial effects of omega-3 fatty acids.
We are now investigating the importance of NATs containing omega-6 fatty acids, which are often considered to be pro-inflammatory. Current projects are exploring roles for this NAT in fatty liver/NASH development, and future work will expand on the in vivo phenotypes we have found.
We use murine models of disease as well as primary cell culture to establish mechanisms, and we collaborate with international and local basic science researchers and clinicians to obtain rare samples (e.g. human liver biopsies, human bile, zoological samples) to establish clinical and biological relevance. We are also conducting the first trial to study functions of NATs in humans.
As an international group, we are seeking a researcher who will fully integrate into our expanding, diverse group. We strive for an inclusive environment that integrates differing scientific perspectives as we enthusiastically investigate this novel and exciting class of lipids.
Further information on the group can be found at: https://bmi.ku.dk/english/research/endocrinology-and-metabolism/grevengoed-group/
Your job
You will be an integral part of the group and work with collaborators and students. Your main tasks would be designing and implementing rodent- and cell-based experiments. The day-to-day tasks include metabolic phenotyping of mouse and cell models. You will be developing assays to investigate the functions of NATs, as well as discovering novel metabolites in collaboration with another team member. We strive to train, teach and mentor the next generation of scientists. With this in mind, you will have the opportunity to mentor more junior lab members and participate in teaching activities for undergraduate students.
Profile
We are looking for a highly motivated and enthusiastic scientist with the following competencies and experience:
Essential experience and skills:
- You have a PhD in a biological science (e.g. biochemistry, physiology, metabolism)
- You have extensive experience in rodent metabolic phenotyping, especially in fatty liver and liver injury models
- You have experience in cell culture, preferably with primary hepatic cells
- You have experience in microscopy and histological analysis of liver
- You have an active interest in biochemistry and physiology/metabolic diseases
- You have an active interest in collaborative research
- Proficient communication skills and ability to work in teams
- Excellent English skills written and spoken
Desirable experience and skills:
- You have experience in immunology/inflammation
- You have experience in co-supervision of MSc and/or PhD students
- You have pre- and postgraduate teaching experience within biochemistry
Place of employment
The place of employment is at the Department of Biomedical Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark. We offer creative and stimulating working conditions in a dynamic and international research environment. Our research facilities include modern laboratories and excellent core facilities with state-of-the-art equipment and support. The department greatly values translational potential and interdisciplinarity.
Terms of employment
The average weekly working hours are 37 hours per week.
The position is a fixed-term position limited to a period of up to 2 years and 9 months. The starting date is 1 April 2024 or after agreement and ending date is 31 December 2026.
Salary, pension and other conditions of employment are set in accordance with the Agreement between the Ministry of Taxation and AC (Danish Confederation of Professional Associations) or other relevant organisation. Currently, the monthly salary starts at 36,400 DKK/approx. 4,800 EUR (October 2023 level). Depending on qualifications, a supplement may be negotiated. The employer will pay an additional 17.1 % to your pension fund.
Foreign and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years.
The position is covered by the Job Structure for Academic Staff at Universities 2020.
Questions
For further information please contact Trisha Grevengoed: grevengoed@sund.ku.dk; www.sund.ku.dk
Foreign applicants may find this link useful: www.ism.ku.dk (International Staff Mobility).
Application procedure
Your online application must be submitted in English by clicking ‘Apply now’ below. Furthermore, your application must include the following documents/attachments – all in PDF format:Motivated letter of application (max. one page).CV incl. education, work/research experience, language skills and other skills relevant for the position.A certified/signed copy of a) PhD certificate and b) Master of Science certificate. If the PhD is not completed, a written statement from the supervisor will do.List of publications.
Deadline for applications: 29 December 2023, 23.59pm CET
We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.