莱顿大学医学中心博士后职位招聘–细胞生物学和分子生物学方向

The position

Would you like to study a newly discovered DNA repair protein and show how it works to repair DNA damage and prevent disease? If so, have a look at the position below!

When breaks in our DNA are not repaired efficiently or correctly, diseases such as cancer can arise. DNA breaks can have different structures and occur in different parts of our DNA. How the DNA repair machinery deals with the structure and context of a DNA break and how this influences the repair process is largely unclear. The Van Attikum lab will use a combination of advanced cellular, genomics and biochemical analyses to study whether a newly discovered repair protein, zinc-finger 384, plays a heroic role in this. For this Dutch Research Council (NWO)-funded project, the Van Attikum lab is seeking a highly motivated postdoc.

Your profile

• You are a very enthusiastic scientist with a critical mindset, holding a PhD
• You have experience in conducting cell biology- and molecular biology-based experiments
• You have experience in protein purification and biochemical assays
• You have at least one peer-reviewed, high-impact first-author publication

What we offer

You will be employed on the basis of a 36-hour week. Appointment is for a temporary period. Your salary will depend on your qualifications and experience, with a minimum of € 3.359 and a maximum of € 5.292,- gross per month based on a 36-hour week (scale 10, CAO UMC). 

Working at the LUMC

The LUMC, situated in Leiden, the Netherlands, is an academic medical center for patient care, research and education, aiming to meet the challenges of tomorrow’s health care. It has a strong focus on research, connecting and combining fundamental research into disease-causing mechanisms with patient-focused studies in areas like oncology, regenerative medicine and population health. The LUMC has research facilities that include capabilities for multiple appliances. The combination with clinical and societal outreach programmes allows for ground-breaking research and innovation in basic and applied science.

The Department of Human Genetics is a broadly oriented research department, focusing on the (epi)genomic contribution to diseases. The department consists of 23 research units, embedded in four overarching research lines. You will work in the research group led by Prof. dr. Haico van Attikum which is embedded in the research line ‘Genome instability and cancer’ and has a clear focus on better understanding the fundamental mechanisms of DNA damage repair to improve clinical management of cancer patients. More specifically, research in the Van Attikum lab aims at identifying and characterizing enzymes that operate during DNA repair processes in human cells using a cross-disciplinary approach that combines novel and cutting-edge genomics approaches with bioinformatics, genetics, biochemistry and high-resolution microscopy. Functional assays are used to study their role in distinct DNA repair pathways (e.g. Caron et al., Gen. & Dev., 2019; Rother et al., Nat. Commun., 2020; Singh et al., Nat. Commun., 2021). The LUMC hosts state-of-the-art facilities for next-generation sequencing, proteomics, microscopy and high-content screening that we use for our research.

More information

A detailed job description can be found at Vacatures | LUMC. You may also contact Professor Haico van Attikum, department Human Genetics, 071 526 96 24, h.van.attikum@lumc.nl.

How to apply

If you wish to apply, please complete our job application form by October 29, 2023.