The Jankowsky lab seeks a postdoctoral fellow to join us in studying how lysosomal protein TMEM106B protects the brain against tauopathy. We’ve shown that constitute deletion of this protein accelerates tau accumulation, microgliosis, neurodegeneration, and cognitive decline in a mouse model of frontotemporal dementia. We are now using cell-type specific targeting strategies to test whether TMEM exerts its protective effect through neurons or microglia. Researchers will work as part of a team combining mouse genetic engineering, viral brain transduction, neurohistology, and basic biochemistry to understand dementia pathogenesis and develop potential treatments. You can learn more about our lab and ongoing projects at our website: https://www.bcm.edu/research/labs-and-centers/faculty-labs/joanna-jankowsky-lab
- Designs and conducts research experiments.
- Selects and determines appropriate research procedures.
- Collects, compiles and analyzes data.
- Conducts literature searches and summarize information needed for particular studies.
- Documents and interpret results of experiments.
- Prepares experimental results for publication and oral presentation
- MD or Ph.D. in Basic Science, Health Science, or a related field.
- No experience required.
- Strong background in molecular biology and neuroanatomy.
- Experience with mouse models of dementia and molecular strategies for genetic engineering.
- Highly self-motivated with outstanding experimental skills.
- Able to think independently but also work well in a team.