瑞典乌普萨拉大学博士后职位招聘–免疫学、血管生物学、肿瘤免疫学、免疫治疗或相关临床前研究领域
Love to solve complex biological problems? Curious to explore the contribution of non-hematopoietic cells to immune regulation – then join us!
The focus of our lab is to understand the impact the highly specialized lymph node vasculature and stromal cells has on the structure and function of the lymph node in the regulation of adaptive immune responses. Particularly we are interested in how stromal dysregulation induced in cancer and by lymphatic metastasis can influence the immune response. We also study the consequences of pathological vascular and stromal lymph node changes in aging. There is possibility to contribute to work that involves using state-of-the-art genetically modified mice (1, 5) to evaluate the role of vascular expressed genes for the immune regulation within the lymph node in homeostasis and in cancer. Another key line of work is focused on human biobank tissue, where we use front-line methods for spatial tissue profiling by in situ RNAseq and multispectral imaging in whole tissue slides from cancer patients (2-4). We work closely with the BioImage Informatics Facility (BIIF) at Uppsala University to develop new and novel solutions for automatic image analysis (3). The person(s) who join us will have possibility to benefit from an inspiring versatile research environment. Since our research questions transverse immunology, vascular biology and cancer biology we also work in collaboration with other groups with all these different interests, and both with highly experimental scientist and with clinical scientist.
Qualifications:
For postdoctoral studies with us you need a PhD within immunology, vascular biology, tumor immunology, immunotherapy or related preclinical research field. Preferentially within the last 3 years. For the work with human tissue, interest in digital spatial image analysis is key. The language used in the lab is English.
Applications should be sent by email to: [Please click the Apply button for the link or address], include motivation letter, CV and 2 references
Department of Medical Biochemistry and Microbiology (IMBIM), Uppsala University, Sweden
More information about our work: https://www.imbim.uu.se/research-groups/infection-and-immunity/Maria+Ulvmar
Recent publications from the lab:
1.) Xiang M, et al., A Single-Cell Transcriptional Roadmap of the Mouse and Human Lymph Node Lymphatic Vasculature. Front. in Cardiovascular Med. 2020 Apr 30;7:52.
2.) Bekkhus T, et al., Remodeling of the Lymph Node High Endothelial Venules Reflects Tumor Invasiveness in Breast Cancer and is Associated with Dysregulation of Perivascular Stromal Cells. Cancers (Basel). 2021 Jan 8;13(2):211.
3.) Bekkhus T, et al., Automated detection of vascular remodeling in tumor-draining lymph nodes by the deep-learning tool HEV-finder. The J. of Pat. 2022 Sep;258(1):4-11.
4.) Bekkhus T et al., Stromal transdifferentiation drives lipomatosis and induces extensive vascular remodeling in the aging human lymph node. The J. of Pat. 2023 Mar;259(3):236-25,
5.) Arroz-Madeira Set al., Lessons of vascular specialization from secondary lymphoid organ lymphatic endothelial cells, Circulation Research, (2023). 132(9): p. 1203-1225.