Are you an ambitious researcher looking for your next challenge? Do you have an established background in immune signalling structural biology? Do you want to further your career in one of the UKs leading research intensive Universities?
We seek to appoint a Research Fellow to the research team led by Prof. Elton Zeqiraj in the Faculty of Biological Sciences at the University of Leeds, Leeds, UK. The successful applicant will undertake biochemical, structural and functional studies of macromolecular complexes involved in ubiquitin cell signalling regulation. The position will suit someone interested in cryo-electron microscopy, immune signalling biology and protein structure.
You should have or be very close to completing a PhD in Structural Biology or a related discipline. You should have a strong background in protein production, cryoEM and structural analysis of protein complexes and co-structures, and experience with challenging cryoEM projects, biophysical methods and enzyme assays. Significant experience with E3 ligases and/or deubiquitinases and experience in cryo-electron microscopy would be advantageous.
The Astbury Centre for Structural & Molecular Biology at the University of Leeds has excellent facilities for cryo-electron microscopy (two Titian Krios 300 kV equipped with Falcon-4 detectors and Selectris energy filters, protein crystallography (crystallisation robots, automatic imaging), and protein production with expertise in multi-subunit expression in insect cell, yeast and bacterial expression systems. The Astbury Centre is also well-equipped with instrumentation for biophysical analysis (e.g. ITC, mass photometry, fluorescence, multi-angle light scattering). Additionally, the University provides state-of-the-art infrastructure for mammalian cell culture, high-throughput screening, imaging, mammalian genetics, chemical biology and proteomics.
The University of Leeds and the Faculty of Biological Sciences are committed to providing equal opportunities for all and offer a range of family friendly policies. The University is a charter member of Athena SWAN (the national body that promotes gender equality in higher education), and the Faculty of Biological Sciences was awarded a Silver award in 2020. We are proud to be an inclusive Faculty that values all staff, and are happy to consider job share applications and requests for flexible working arrangements from our employees. Our Athena SWAN webpage provides more information.