Applications are invited for a Postdoctoral Research Fellow position funded by a Wellcome Trust Investigator Award to Professor Mala Maini in the Division of Infection and Immunity. Work within the Maini lab aims to translate advances in the understanding of pathogens, cancer and the immune system into improved diagnosis and therapy. The lab is based within UCL’s Institute of Immunity and Transplantation, housed in the newly built Pears Building in Hampstead. Its close links to the adjacent Royal Free London hospital provide an excellent interface between science and medicine. Professor Maini strengthens this translational focus by her own clinical links and those of her clinical colleagues.
The Division of Infection and Immunity provides an effective infrastructure for immunology/virology research and a lively and sociable environment, always striving for excellence. There is an established track record for post-docs gaining personal fellowships, with Mala having successfully supported seven of these just in the last couple of years; independently minded and talented investigators will be encouraged and supported in seeking such fellowship support.
Information about the Research Project and Lab
The successful candidate will join a dynamic group of basic and clinical scientists all working on integrated aspects of the immunopathogenesis and immunotherapy of hepatitis B, liver cancer and SARS-CoV-2, with a number of leading national and international collaborators. The post-holder will work on a cutting-edge programme of work funded by a highly prestigious Wellcome Trust award, collaborating with other group members and assisted by the lab technicians. The lab’s central research goal is to re-direct adaptive immune responses to control hepatotropic pathogens and tumours (specifically, hepatitis B virus and hepatocellular carcinoma). Our detailed delineation of the unique immune cellular interactions and metabolic niche within the tolerogenic liver environment is informing the development of tailored therapeutic approaches. More recently, we have applied our experience in comparing successful and dysfunctional antiviral T and B cells, including the tissue-resident component, to SARS-CoV-2.
About the role
This post will be predominantly focused on examining mechanisms to reconstitute T cell responses towards HBV and hepatocellular carcinoma, working with mouse models, in vitro models and patient samples. An additional area of work is the lab’s recent focus on adaptive immune responses to SARS-CoV-2 and the optimisation of next-generation mucosal pan-coronavirus vaccines.
The post is available to start as soon as possible, for one year in the first instance.
Candidates should have a PhD or equivalent in a relevant subject. Significant experience of research in human and murine cellular immunology including a high level of competency at cell culture and multiparameter flow cytometry is required. The candidate needs to be prepared to work flexible hours and have hepatitis B immunity.
What we offer
As well as the exciting opportunities this role presents, we also offer some great benefits some of which are below:
• 41 days holiday per year (27 days annual leave, 8 bank holiday and 6 closure days)
• Additional 5 days annual leave purchase scheme
• Defined benefit career average revalued earnings pension scheme (CARE)
• Cycle to work scheme and season ticket loan
• Immigration loan
• Relocation scheme for certain posts
• On-Site nursery
• On-site gym
• Enhanced maternity, paternity and adoption pay
• Employee assistance programme: Staff Support Service
Visit https://www.ucl.ac.uk/work-at-ucl/reward-and-benefits to find out more.
Our commitment to Equality, Diversity and Inclusion
As London’s Global University, we know diversity fosters creativity and innovation, and we want our community to represent the diversity of the world’s talent. We are committed to equality of opportunity, to being fair and inclusive, and to being a place where we all belong. We therefore particularly encourage applications from candidates who are likely to be underrepresented in UCL’s workforce. These include people from Black, Asian and ethnic minority backgrounds; disabled people; LGBTQI+ people; and for our Grade 9 and 10 roles, women.
Our department holds an Athena SWAN Silver award, in recognition of our commitment and demonstrable impact in advancing gender equality.