美国波士顿儿童医院博士后职位招聘–分子生物学/小鼠遗传学方向

Postdoc Position in Cardiovascular Genomics and Regeneration .

A postdoc position is available in the lab of Dr.Miao Cui(miao-cui.com)in Boston Children’s Hospital at Harvard Medical School to study genomic control mechanisms of heart regeneration and pathological remodeling.

Dr . Cui has a joint position as a tenure-track Assistant Professor in the Department of Genetics at Harvard Medical School and the Department of Cardiology at Boston Children’s Hospital.

The lab is located at the center of Harvard Longwood Medical Campus, immersed in a highly interactive and collaborative scientific environment . Dr. Cui obtained her Ph.D.from California Institute of Technology in the lab of Dr.Eric Davidson and Postdoctoral training at UT Southwestern mentored by Dr.Eric Olson.

Her research on cardiac regeneration and disease led to several high-profile publications on Developmental Cell, Nature Communications.PNAS.Nature MedicineScience Translational Medicine and Cell Reports

Research Summary:

Adult mammalian hearts lack the ability to regenerate and instead respond to injury with maladaptive remodeling that leads to heart failure.

In contrast the newborn mouse heart can effectively regrow the damaged tissue.Understanding how neonatal mouse hearts regenerate following injury provides an exciting new inroad into the possible mechanisms of cardiac regeneration and repair in adults.

Our lab aims to use systems-level approaches to discover the basic biological mechanisms underlying neonatal heart regeneration.We leverage this information to identify therapeutic targets and translate these findings into studies of human cells and therapies for heart disease patients.

We uncovered previously unknown cellular components specific to neonatal heart regeneration, filling gaps in our knowledge of new heart muscle cell sources during regeneration and advancing our understanding of the role of the cardiac microenvironment in tissue healing.

We are currently exploring these novel cell populations. which we believe have the potential to open up new areas of research in regeneration and beyond. We are also taking systems biology approaches to identify factors and pathways that regulate various aspects of the regeneration process and using gene Mending injured adult heart by targeting delivery approaches to explore their therapeutic potential for gene regulation treating heart disease.

Our research combines genetics single-cell and spatial transcriptomics ,tissue 3D imaging Neonate Injury Adult cardiac injury models in mice, high-throughput screening in primary cardiac cells and human heart organoids as well as cardiac(patho) physiology.

The long-term goal of our research program is to understand the mechanisms underlying the distinct reparative abilities of different cardiac cell types during neonatal heart regeneration vs.pathological remodeling in adults, and ultimately to generate a comprehensive cellular Targeting transcription factors
and molecular blueprint for targeting cardiac regeneration in adult humans.

The ideal candidate must hold a Ph.D.and/or M.D.degree and have a background in molecular biology and mouse genetics with an interest in Genomics and Cardiovascular Biology.Candidates should be able to work independently and have demonstrated English verbal and writing skills. Interested individual should send a CV ,a statement of research interests as well as the names and contact inform for three references to:Miao Cui, Ph.D. Email Miao.Cui@childrens.harvard.edu