Umeå University is dedicated to providing creative environments for learning and work. More than 4300 employees and 33979 students from over 60 nationalities have already chosen Umeå University. The recent breakthrough research from Umeå include deciphering the molecular mechanisms of the bacterial CRISPR-Cas9 system and repurposing it into a tool for genome editing, a method developed at Umeå University that was awarded Nobel Prize in Chemistry 2020.
The labs are located within the cross-disciplinary Chemical Biological Centre at Umeå University and are affiliated with Umeå Centre for Microbial Research, a Centre of Excellence Sweden. The labs are fully equipped for biological and chemical research with access to excellent facilities and state-of-art equipment and platforms in a creative, inspiring, international and highly interactive environment. Facilities include Protein Expertise Platform, X-ray, proteomics, NMR (850-400 MHz), cryo-EM and Biochemical Imaging Centre (confocal, FLIM, spinning disk, TIRF, STORM).
Positive-sense RNA viruses (+ssRNA viruses) are a large group of human pathogens including coronaviruses. Autophagy is an evolutionarily conserved catabolic process to eliminate or recycle dysfunctional cellular organelles or unused proteins. The project focuses on the involvement of autophagy in +ssRNA virus infection.
The Wu lab has elaborated a novel mode of action for virulent bacteria (Legionella pneumophila, Vibrio cholerae) affecting host autophagy (eLife2017, JCS 2021, JCB 2022). We have identified novel chemotypes for autophagy modulation and new cellular pathways involved in new mechanisms of autophagy regulation (Angew Chem 2017, Nat Chem Biol2019, Autophagy 2021, Angew Chem 2022).
The Carlson lab studies biochemical and structural aspects of +ssRNA virus replication. We used cryo-electron tomography to show that poliovirus assembly takes place directly on membranes and is dependent on the autophagic lipid kinase VPS34 (Nat Comms 2022). We further elucidated the first structures of the full replication organelle of alphaviruses (eLife, 2022).
The project will combine expertise from both labs, using novel cell biology methods combined with high-end proteomics and cryo-electron tomography to understand how the autophagy machinery is used for the replication or restriction of a diverse set of positive-sense RNA viruses.
The project is interdisciplinary with strong collaborations across scientific disciplines. The 2-year fellowship (672 000 SEK) is tax-exempt with start as soon as possible.
To qualify as a postdoctoral fellowship holder, the postdoctoral fellow is required to have completed a doctoral degree or a foreign degree deemed equivalent to a doctoral degree in cell biology, biochemistry, molecular biology, structural biology, virology or in another relevant field. This qualification requirement must be fulfilled no later than at the time of the decision about fellowship recipient, but we welcome applications from candidates who are in the process of obtaining their doctoral degree.
Preference should be given to applicants who received their degree no more than three years before the end of the application period. Applicants who received their doctoral degree earlier may be considered in special circumstances. Special circumstances include absence due to illness, parental leave, clinical practice, elected positions in trade unions, or similar circumstances.
The successful candidate is expected to independently further their own studies but also be in close collaboration with other members of the team. Independence and good ability to collaborate are therefore requirements. Good command of written and spoken English is also a requirement.
Experiences in cell imaging, western blotting, siRNA, CRISPR-Cas9, molecular cloning, protein expression and purification, and proteomics are strong merits, as is a good record of research publication.
The application should include:
- Cover letter including research interests, qualifications and motivation for applying (max 2 pages),
- CV including list of publications,
- Verified copy of doctoral degree certificate or documentation that clarifies when the degree of doctor is expected to be obtained,
- Copy of max 3 relevant research articles,
- Contact information of two persons willing to act as references,
- Other documents that the applicant wishes to claim.
Submit your application as a single PDF marked with the “Postdoc application” in the subject field of the email, to firstname.lastname@example.org and email@example.com. Application deadline is 31 May 2023.
For more information, please contact:
Professor Yaowen Wu, Department of Chemistry, https://www.umu.se/en/research/groups/yaowen-wu/
Dr. Lars-Anders Carlson, Department of Medical Biochemistry and Biophysics,
More about the employer
At Umeå University, everything is nearby. Our cohesive campus environment makes it easy to meet, collaborate and exchange knowledge, which promotes a dynamic and open culture where we rejoice in each other’s successes. If you are interested in knowing about Umeå University as a workplace, read more at: https://www.umu.se/en/work-with-us/.
Umeå University also offers a strong postdoc community with the Umeå Postdoc Society (UPS), which fosters networking amongst postdocs, organises social and career development events and works towards improving the postdoc experience at Umea campus. Check out their website: https://umeapostdocsociety.se/, and do not hesitate to get in contact with them early on!
We welcome your application!