We are seeking a highly-motivated Postdoctoral Fellow with strong leadership ability and well-rounded, hands-on expertise in cancer biology, protein biochemistry, mass spectrometry, and molecular biology. The successful applicant will work full-time under the supervision of Dr. Philipp Lange PhD (Canada Research Chair in Translational Proteomics of Childhood Cancer) for a two-year term with the possibility of extension. This position is CIHR funded and the start date is flexible.
You will lead a CIHR-funded project on the characterization and targeting of a new class of highly specific cell surface epitopes in childhood cancer. You will use and advance new mass spectrometry approaches developed by our group to study the cell surface of primary pediatric cancer specimens and model systems and will use and advance cell biological and biochemical approaches to develop new modes to target and monitor malignant cells. You will develop leads for target-specific binding molecules and elucidate mechanisms underlying the occurrence of theragnostic targets. You will also have the opportunity to supervise graduate and undergraduate students, gain leadership experience in collaborative projects and contribute to grant applications. If of interest we will work with you in the latter half of your fellowship to develop a secondary project that provides preliminary data for your first independent position and grant. We are looking for a team member to spearhead and shape the project over a period of 3-5 years and provide a very dynamic yet supportive interdisciplinary environment with dedicated mentoring and excellent opportunities for continued career development.
- Provide leadership, strategic direction, and basic/translational research pertaining to research in cancer proteomics pertaining to the discovery and characterization of new therapy targets
- Design and implement research plans to investigate the cell surface proteome and its modulation in pediatric malignancies and develop target strategies
- Foster research collaborations and work jointly with academic, clinical, industry, and other partners
- Scientifically document lab experiments, data analysis, interpretations
- Write manuscripts, and present results at internal and external meetings
- Identify funding opportunities as well as write grant proposals with supervisor as a co-applicant
- Lead and mentor junior trainees in the laboratory
- PhD with expertise in proteomics, protein purification, protein biochemistry, mass spectrometry, and/or cancer biology
- A proven track record with a minimum of 2-3 first author publications in reputable journals
- Previous hands-on experience in functional cell biology and proteomics of PTMs is an asset
- Strong statistical foundation and expertise in R or python for data analysis
- Fluent in written and spoken English and demonstrated excellence in scientific writing
- Previous experience in proposal/grant writing is an asset
- Excellent written and oral communication skills
- Exceptional interpersonal and organizational skills
- Expertise in proteolytic processes and protease biology is an asset
- Hands-on expertise in CRISPER genome editing, mass spectrometry, flow cytometry, processing of small sample amounts / single cell proteomics, cell surface characterization and secretome characterization are important assets.
Self-starter; Demanding of excellence; Attentive to details; Committed while able to maintain balance and perspective; Willing to make and learn from mistakes; Person of high integrity; Honest, trustworthy, positive, and respectful; Accountable; Flexible; Gets along well with others; Good listener, straightforward communicator, team builder; Capable of working independently and in teams; Comfortable with responsibility and uncertainty; Looking to build something of value; A good sense of humour; Excellent social, networking and interpersonal skills.
RESEARCH TEAM & ENVIRONMENT:
Located at the BC Children’s Hospital Research Institute (BCCHR) (www.bcchr.ca), the leading pediatric research center in Western Canada, you will be embedded in the highly innovative and interdisciplinary research environment spanning BC Children’s Hospital, UBCand BC Cancer. Vancouver repeatedly ranks among the most livable places in the world and combines excellence in research with high quality of life. Excellent opportunities for personal and professional development are available.
You will be part of a dynamic team of experimental and computational scientists and part of local and national collaborations. You will have direct access to state-of-the-art cell and molecular biology facilities, mouse and chicken chorioallantoic membrane (CAM) modeling platforms, mass-spectrometry, next-generation sequencing, flow cytometry, imaging and compute infrastructure. More information on the Lange Laboratory can be found at https://langelab.med.ubc.ca/.
You will be employed by the Department of Pathology and Laboratory Medicine, Faculty of Medicine at the University of British Columbia and will be based at the Lange Laboratory located within BC Children’s Hospital Research Institute. You will report directly to Dr. Lange and will play a senior leadership role in the laboratory that includes overseeing the research activities of graduate students, undergraduate students, and technicians.
CONSEQUENCE OF ERROR:
This is a senior research position that plays a critical role in the development of this novel field. The PDF is accountable for the quality and integrity of the research and data, including analyses and interpretation, as well as the effective and efficient management of research projects and deliverables. This position requires innovation, strategic planning, and adaptability. Incorrect decisions or actions may damage the reputation of the laboratory, lead to loss of credibility in this field, and be financially costly.
The PDF will work with a high degree of independence and set priorities under broad directives from Dr. Lange. This position will also provide the candidate with professional development opportunities as well as a high level of exposure to translation, commercialization, and industry.
The PDF will be expected to provide direction and mentorship to graduate and undergraduate students under the supervision of Dr. Lange.
Job title: Postdoctoral Fellow in Cancer Biology – Cell Surface Target Discovery – Proteomics (Lange Lab)
Employee Group: Faculty
Department: Pathology & Laboratory Medicine
FTE: Full time
Salary: $50-$80k, depending on project-relevant skills and experience
How to apply: Please send the following as one PDF file to email@example.com: cover letter expressing your long-term research vision, career goals and fit for the position, intended start date and relocation plans, if applicable); CV; contacts for three references; copies of your most impactful papers (max 3, submitted OK). The position will remain open until filled.
This position is located within a health-care facility. Therefore, this position requires successful verification of full vaccination against Covid-19 provided prior to the start date, as required by the provincial health mandate.
This posting is for the UBC Vancouver campus in British Columbia, Canada.
Please refer to reference number NC-56585 during correspondence about this position.
Equity and diversity are essential to academic excellence. An open and diverse community fosters the inclusion of voices that have been underrepresented or discouraged. We encourage applications from members of groups that have been marginalized on any grounds enumerated under the B.C. Human Rights Code, including sex, sexual orientation, gender identity or expression, racialization, disability, political belief, religion, marital or family status, age, and/or status as a First Nation, Metis, Inuit, or Indigenous person.
The University of British Columbia is a global centre for research and teaching, consistently ranked among the top 20 public universities in the world. Since 1915, UBC’s entrepreneurial spirit has embraced innovation and challenged the status quo. UBC encourages its students, staff and faculty to challenge convention, lead discovery and explore new ways of learning. At UBC, bold thinking is given a place to develop into ideas that can change the world.
Postdoctoral Fellows at UBC Vancouver
UBC is home to over 900 postdocs spanning all faculties and units across two campuses and a variety of affiliated hospitals, research centres, and sites, providing unparalleled opportunities to learn, discover and contribute in one’s own way. UBC’s Postdoctoral Fellows Office (PDFO) is committed to supporting the lives and career aspirations of our Postdocs, with the goal of enriching their experience at UBC and preparing them for the future. In addition to providing support and advocacy for all postdocs, the PDFO is dedicated to providing professional development opportunities that foster the development of soft skills needed in today’s professional environments, helping them secure future careers in their chosen fields.
About UBC’s Faculty of Medicine
Every day across British Columbia, trainees and researchers at the UBC Faculty of Medicine are turning skills into jobs, investments into discoveries, and discoveries into solutions that are transforming health for everyone.
The UBC Faculty of Medicine offers a diverse array of training opportunities including cutting-edge research experiences in the biosciences, globally recognized population health education, quality health professional training, as well as several certificate and online training options. The Faculty of Medicine is home to more than 1,700 graduate students housed in 23 graduate programs (14 of which offer doctoral research options). Year after year, research excellence in the Faculty of Medicine is supported by investment from funding sources here at home and around the globe, receiving approximately $1.6B in total research funding in the last five years.
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