Postdoctoral Researcher – Protein Crystallography and Drug Discovery
University of Oxford
We are seeking to appoint a highly motivated Postdoctoral Researcher with experience in protein crystallography to join the Alzheimer’s Research UK Oxford Drug Discovery Institute, where you will be part of a larger team carrying out research into new dementia targets at Centre for Medicines Discovery.
Reporting to the Assay Development and Screening Team Leader (Dr Emma Murphy), you will become an integral part of target-based project teams working on drug discovery projects and employ cutting-edge structural and biophysical/biochemical research to characterise new proteins and carry out mechanism of action studies. You will be responsible for performing fragment screening experiments on targets involved in Alzheimer’s disease and other neurodegenerative diseases causing dementia and be expected to take the lead in advancing initial fragment hits to potent compounds by closely collaborating with computational and medicinal chemists and to guide the elaboration process through crystallographic and biophysical analysis.
It is essential that you hold a PhD (or close to completion) around protein crystallography/in biochemistry or a related subject together with relevant laboratory experience. Having a strong background in protein crystallography and biochemistry/enzymology is essential and you will have experience in protein production using bacteria, insect cells and mammalian expression systems. You will be able to manage your own research with an eye for detail and take responsibility for administrative activities such as management of lab reagent stock and lab book writing.
Applications for this vacancy are to be made online and you will be required to upload a supporting statement and CV as part of your online application. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience.
This position is offered full time on a fixed term contract for 2 years and is funded by Alzheimer’s Research UK.
Only applications received before 12 midday on 06 February 2023 will be considered. Please quote 162034 on all correspondence.