英国牛津大学博士后职位招聘—基因组稳定性

Postdoctoral Researcher in Genome Stability

University of Oxford

Postdoctoral Researcher in Genome Stability

Department of Oncology, Old Road Campus Research Building, Headington, Oxford, OX3 7DQ

This is a re-advertisement. Previous applicants need not re-apply

About the role

Applications are invited from enthusiastic, motivated individuals for a CRUK- funded Postdoctoral Researcher position for Professor Madalena Tarsounas’s Group, within the Department of Oncology. You will join an exciting research programme which combines cell/molecular biology and microscopy approaches with high-throughput technologies and bioinformatics to understand how BRCA1 and BRCA2 facilitate DNA replication and how this, in turn, impacts chromosome segregation during mitosis. We have recently mapped genome-wide the sites where mitotic DNA synthesis occurs in BRCA1/2-deficient cells (Groelly et al. , Molecular Cell 2022; PMID: 36002001), using state-of-the-art technologies (e.g. MiDAS-seq, high-content microscopy) and found that they co-localise with sites of R-loop formation. We now aim to investigate the roles of ATR/ATM kinases, as well as of MUS81 (Lai et al. Nat. Communications 2017) and other nucleases in regulating this process.

In this role, you will work as part of a team of Postdoctoral Researchers, collaborating with researchers from across the University of Oxford’s various technology platforms. You will be responsible for developing and testing your own hypotheses, generating high-quality and reproducible data, participate in dissemination activities and aid in manuscript preparation. You will also be required to provide guidance/supervision to other members of the research group, including PhD/MRes students.

The position is based in the Department of Oncology, Old Road Campus Research Building, Headington, Oxford, OX3 7DQ and is offered on a full-time, fixed- term basis for three years.

An early start date is required.

About you

You will hold (or be very close to completing) a DPhil/PhD in Oncology, Biology or other related discipline, together with relevant experience. Experience in DNA damage signalling and repair is essential, together with computer literacy and a good record of publication(s) in internationally recognised journals. Experience with analysis of ChIP-seq and/or EdU-seq data would be advantageous.

Application Process

Applicants should read the job description before completing their application. You will be required to upload a supporting statement, setting out how you meet the selection criteria, a CV, including a statement of career interests, and the contact details of two referees as part of your online application.

Informal enquiries can be directed to Professor Madalena Tarsounas: madalena.tarsounas@oncology.ox.ac.uk

Only applications received by 12pm GMT on Friday 20 January 2023 will be considered.

Committed to equality and valuing diversity

Contact Person : HR Officer Vacancy ID : 162202 Contact Phone : Closing Date & Time : 20-Jan-2023 12:00 Pay Scale : STANDARD GRADE 7 Contact Email : recruitment@oncology.ox.ac.uk Salary (£) : Grade 7: £34,308 – £35,333 per annum (up to first two points on scale available)