瑞典哥德堡大学博士后职位—RNA生物学

Postdoctoral fellow in RNA biology

Postdoctoral fellow in RNA biology

A postdoctoral position is available immediately to study the role of RNA interference (RNAi) in cancers. The project is a collaboration between the Sarshad lab (www.sarshadlab.com) at the University of Gothenburg and the Oligonucleotide unit at AstraZeneca. Gothenburg, Sweden is a national hub for therapeutic oligonucleotide research and in this project, you will have access to state-of-the-art facilities, cutting-edge research tools and you will work at the interface of basic and industry research.

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Project Description

The research focus of the Sarshad lab is to study small non-coding RNAs and Argonautes (AGO) proteins in disease models and through development. Small RNAs and AGOs silence target mRNAs and contribute to gene regulation in both the cytoplasm and the nucleus. Despite many reports documenting the presence of the RNAi machinery in cell nuclei, nuclear RNAi has remained largely overlooked, and its potential unexplored. Therefore, uncovering the molecular mechanism of nuclear RNAi and the role of AGO will deliver identification of new pathways to modulate gene expression. The applicant will benefit from extensive collaboration with AstraZeneca and the Sarshad lab to better understand basic regulation of RNA interference.

Duties

The postdoctoral researcher will be leading a project aimed at better understanding the mode of action of small interfering RNAs (siRNAs) in cancer models. The successful candidate is expected to work independently, give critical input to the project, and design experiments together with the supervisor.

Assessment criteria

We are looking for a highly motivated individual with a recent PhD in RNA biology. The candidate should have documented track record in biochemical and molecular biology techniques. Essential techniques are extensive experience with cell culture, western blotting, PCR, qPT-PCR, DNA and RNA gel electrophoresis, cloning and transfections (plasmids and siRNAs). Furthermore, it is a strong merit if the candidate has experience in small RNA library preparation for CLIP assays. The ability to use and knowledge of simpler bioinformatic tools such as in R or in Python is a strong merit.

The successful candidate is expected to be highly motivated, capable to plan and execute experiments independently and to actively contribute scientifically to the group. These skills should be reflected in publication records.

Fluency in spoken and written English is a must. A major emphasis will be placed on personal suitability

Regulations for the evaluation of qualifications for academic positions are given in Chapter 4, Section 3 – 4 of the Higher Education Ordinance.

Employment

The employment is full time and temporary, two years with the possibility of one year’s extension, with placement at the Institute of Biomedicine. First day of employment as agreed.

Contact information

If you have any questions about the position, please contact Aishe Sarshad, Assistant professor, phone number 031-786-5704 or email aishe.sarshad@gu.se

Application

Submit your application via the University of Gothenburg’s recruitment portal by following this link and clicking the “Apply” button. It is your responsibility to ensure that the application is complete as per the vacancy notice, and that the University receives it by the final application deadline.

The application should contain:

– A cover letter giving a brief description of previous research experience, and a motivation to why you are applying

– A CV including a list of publications

– Proof of completed PhD

– Contact details of two references

Last day to apply is January 15, 2022