Transcriptional Regulation & Ribosome Biogenesis in Hematopoiesis & Leukemia
Division of Hematology & Oncology, University of Pennsylvania
Position: The Paralkar Lab (https://paralkarlab.med.upenn.edu/) is seeking postdoctoral researchers for two NIH-funded positions (NIGMS R35 and NHLBI R01) to study coding and noncoding gene transcription and ribosome biogenesis in normal and leukemic hematopoiesis. We are a highly-collaborative group in the vibrant and interdisciplinary ecosystem of the University of Pennsylvania.
Research: Transcription factors and chromatin-binding proteins regulate the transcription of coding and noncoding genes that collectively dictate the fates of normal cells, and are dysregulated in malignant transformation. This includes the transcription of ribosomal RNA, the most abundant RNA in the cell, which is tightly regulated across the normal and leukemic hematopoietic tree. The Paralkar Lab is interested in understanding how transcription and chromatin factors regulate mRNA networks, rRNA transcription, and ribosome biogenesis during hematopoietic stem cell self-renewal, myeloid lineage differentiation, and leukemogenesis. See our most recent work for further details:
Control of ribosomal RNA synthesis by hematopoietic transcription factors, Antony C…Paralkar VR. Molecular Cell (2022)
Customized genomes for human and mouse ribosomal DNA mapping, George SS…Paralkar VR. bioRxiv (2022), under review
Approaches: Work in our laboratory spans a range of approaches, including mouse models of hematopoiesis and leukemia, human and mouse primary tissues and cell lines, flow cytometry, chromatin assays including ChIP and chromosomal looping, FISH and nuclear imaging, chromatin proteomics, targeted protein degradation, high-throughput sequencing approaches including ATAC-Seq, ChIP-Seq, RNA-Seq, single cell RNA-Seq, and advanced bioinformatic and computational pipelines. Research projects may contain wet-lab and/or dry-lab components based on the strengths and interests of each applicant.
Qualifications: Applicants must have a PhD, and proficiency with molecular biology and cell biology techniques. Experience in the epigenetics/chromatin/transcription/ribosome arenas is welcome. Experience with mouse hematopoiesis or mouse models of leukemia is a plus. We are dedicated to improving diversity, and invite applications from groups that are traditionally underrepresented in science.
Apply: Please email the following to Dr. Vikram Paralkar at firstname.lastname@example.org.
1. CV or NIH Biosketch
2. Brief description of your research interests
3. Contact information for three references (reference letters are not required for initial inquiry)