Postdoctoral opportunities are available in Dr. Shuying Sun’s laboratory at Johns Hopkins University School of Medicine. The lab explores the fascinating frontiers of RNA metabolism dysfunction in neurodegenerative diseases by combining molecular and cellular approaches, proteomic, genomic and CRISPR screening platforms.
The nervous system has extremely complex post-transcriptional regulation. The dysfunction of RNA metabolism and protein homeostasis has emerged to play crucial roles in multiple neurological diseases. Mutations and pathologies of several RNA-binding proteins are found to be associated with neurodegeneration, including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and Alzheimer’s disease (AD). An alternative RNA-mediated toxicity arises from microsatellite repeat instability in the human genome. The expanded repeat-containing RNAs could potentially induce neuron toxicity by disrupting protein and RNA homeostasis through various mechanisms.
The Sun lab is interested in deciphering the molecular mechanisms and screening for novel modifiers of disease pathogenesis. We seek to translate the mechanistic findings to therapeutic biomarker and drug target development to advance treatment options against neurodegenerative diseases. We are looking for highly motivated postdoc fellows with solid PhD training in biochemistry, molecular and cellular biology. Experiences with RNA biology, bioinformatics or neuroscience are preferred but not limited to. You will join a strong and highly interactive science community at Johns Hopkins University. Interested candidates should provide a cover letter (with statement of research interest and career goals), CV and the contact information for three references to Dr. Shuying Sun at email@example.com. Please visit our lab website at http://labs.pathology.jhu.edu/sun/ for additional information.