Postdoctoral Fellow in Immunology
The Ricardo-Gonzalez Lab at the University of California San Francisco is seeking an independent and highly motivated postdoctoral fellow to study tissue lymphocytes in health and disease states. Our overarching goal is to understand how tissue-resident immune cells respond to physiologic and pathologic stimuli and how they can influence changes across multiple cell lineages in barrier tissues. We use the skin as our primary model tissue but have broad interests in other tissues. We combine animal models, immunoassays, multi-omics approaches, and microscopy to dissect these circuits. The postdoctoral fellow will focus on studying an aspect of these cross-communications and how the associated functional consequences contribute to tissue function.
Recent related publications:
Ricardo-Gonzalez, R. R. et al. Tissue signals imprint ILC2 identity with anticipatory function. Nat Immunol 19, 1093-1099, doi:10.1038/s41590-018-0201-4 (2018).
Ricardo-Gonzalez, R. R. et al. Tissue-specific pathways extrude activated ILC2s to disseminate type 2 immunity. J Exp Med 217, doi:10.1084/jem.20191172 (2020).
Ricardo-Gonzalez, R. R. et al. Innate type 2 immunity controls hair follicle commensalism by Demodex mites. Immunity, doi:10.1016/j.immuni.2022.08.001 (2022).
Ongoing research efforts in our group aim to:
1. Elucidate how immune cells and their outputs alter tissue niche composition and molecular networks in homeostasis and disease.
2. Dissect molecular mechanisms of how type 2 immunity co-opts allergic and regenerative immune functions to preserve and protect tissue function from the detrimental effects of chronic pathogenic inflammation.
3. Explore the therapeutic use of innate lymphoid cells (ILCs) as adjuvant therapies to treat infection and cancer.
Candidates should have general interests relevant to these topics. In addition, the postdoctoral candidate will have opportunities to apply for grants and fellowships and to pursue independent research directions.
The successful candidates will have a Ph.D., M.D./Ph.D., or M.D. in one of the following fields: immunology, physiology, genetics/epigenetics, or other life sciences. We highly encourage applications from candidates who have recently completed, or will soon complete, their Ph.D. In addition, the candidate must have strong analytical, oral, and written communication skills demonstrated with publication in peer-reviewed journals.
Candidates who have experience with -omics data analysis (scRNA-seq, bulk RNA-seq, ATAC-seq) and/or that are adept at utilizing concepts of genomic engineering and CRISPR to manipulate the function of immune and/or epithelial cells. Quantitative microscopy skills are a plus.
How to apply:
Interested candidates should send a current CV, a 1-page cover letter describing current and future research interests, and names and contact information for 3 references to Roberto Ricardo-Gonzalez (Roberto.Ricardo-Gonzalez@ucsf.edu). Informal inquiries are welcome.
About the University of California San Francisco
The Ricardo-Gonzalez lab is located at the UCSF Parnassus Campus, San Francisco, CA. Our lab is affiliated with the UCSF Biomedical Sciences graduate program, the UCSF Bakar ImmunoX initiative, and the UCSF Benioff Center for Microbiome Medicine.
The University of California San Francisco is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, protected veteran or disabled status, or genetic information.
UCSF provides a comprehensive benefits package.