A postdoctoral fellow position is available in the Tsai laboratory at Baylor College of Medicine to investigate the mechanism and 3D structure of ATP-dependent protein quality control machines and related stress-response proteins (Cell Rep. 2019; J. Mol. Biol. 2019; Nature Commun. 2021; Proteins, 2022). The successful applicant will be highly motivated, able to work independently and as a team member, and possess excellent communication skills. S/he will join a multi-disciplinary team that uses systems biology methods to address questions of high biomedical significance to understand the etiology and molecular basis of metabolic and neurodegenerative diseases. The successful applicant will use structural biology methods; perform experiments in biochemistry and enzymology; analyze data; and prepare manuscript drafts. Scholarship and enthusiasm for experimental research are expected.
- Plan, direct and conduct specialized and advanced research experiments.
- Evaluate and analyze data.
- Establish new research protocols and procedures.
- Summarize research findings and publish results in peer-reviewed journals.
- Responsible for laboratory operations.
- Supervise research staff.
- Ph.D in Basic Science, Health Science, or a related field.
Experience with recombinant protein expression and purification (IEX, HIC, SEC); determining binding parameters using FP, BLI, ITC, or SPR; site-directed mutagenesis; and conducting enzyme assays is required. Training in protein crystallography and cryoEM/ET will be provided. Experience with tissue culture or working with a model organism (bacteria, yeast, or worms) is an advantage
Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.