The Chua Lab at the Johns Hopkins Institute for Cell Engineering is currently seeking to hire a qualified Postdoctoral Fellow for a project using human induced pluripotent stem cell (iPSC)-derived neurons, CRISPR/Cas9, and super-resolution fluorescence microscopy to study autophagy in the context of Parkinson disease and related neurodegenerative disorders. The Postdoctoral Fellow will be hired for a period beginning ASAP and going through the summer of 2024, with the possibility of extending this term pending project outcomes and funding support. Using biochemical and microscopy methods in iPSCs differentiated into neurons and other cell types, the Postdoctoral Fellow will collaborate on research projects to interrogate and discover novel mechanisms of the autophagy pathway and turnover of autophagy substrates. Teaching and service duties will be exempted, and full-time effort will be devoted to research. The position will remain open until filled. Applications will be accepted on a rolling basis.
The position requires a strong background in autophagy, stem cell biology, biochemistry, genetics, neurodegenerative diseases, statistics, and microscopy. Applicants should have a PhD or expect to complete a PhD by Fall 2022 in a relevant neuroscience field from an accredited institution and demonstrate a record outstanding scholarship. Responsibilities will include: learning proficiency in and maintaining iPSC lines, transient transfection, autophagy assays, designing and troubleshooting CRISPR/Cas9 gene editing, DNA purification, PCR, RNA extraction, RT-PCR, Western blot, immunocytochemistry, microscopy usage and maintenance, data records keeping, statistical analysis, training junior lab personnel, assistance in lab management and upkeep, manuscript composition, scientific communication and presentations, and assistance in grant writing. Applicants will receive a small research budget to be used at their discretion, including to cover the costs of travel and research for the project.
A complete application must include:
- Current curriculum vitae
- Statement of research interests
- Representative manuscript or publication
- Contact information for two referees, who will be contacted directly be email and asked to comment specifically on your qualifications for the proposed project
The Johns Hopkins University is committed to equal opportunity for its faculty, staff, and students. To that end, the university does not discriminate on the basis of sex, gender, marital status, pregnancy, race, color, ethnicity, national origin, age, disability, religion, sexual orientation, gender identity or expression, veteran status or other legally protected characteristic. The university is committed to providing qualified individuals access to all academic and employment programs, benefits and activities on the basis of demonstrated ability, performance and merit without regard to personal factors that are irrelevant to the program involved. Successful candidate(s) for this position will be subject to a pre-employment background check.