Department of Cellular & Molecular Pharmacology, University of Miami School of Medicine
Research direction: Posttranslational protein arginylation and the associated protein modifications including ubiquitination, acetylation and proteolytic cleavage.
Arginylation is the addition of one extra arginine to proteins catalyzed by an enzymatic reaction. The study of arginylation is an emerging direction with many unanswered fundamental questions. Our lab is aimed to understand arginylation from the perspectives of protein degradation, stress response, and metabolism. These studies are mainly done in the context of cancer (prostate and breast), injury, and inflammation. We are also interested in developing new research techniques and screening for drug candidates. A wide range of test models including yeast, mammalian cell lines, and live animals (mouse and rat), a well as human tissue samples are currently being used in our investigations.
The anticipated postdoctoral researcher will be able to work on highly multi-disciplinary projects with flexibility to develop their own research directions. Our lab is highly nurturing for the career development of the trainees. Among our past trainees, 40% now hold tenure-track or permanent academic positions while 60% are in major pharma- or biotech companies.
Ideal candidates for this position should have research background in at least one of the below topics. We are also happy to train highly motivated individuals.
Ubiquitin and proteasome; ROS and stress response;
Mitochondria, glycolysis and general metabolism; Protein modifications and proteolysis;
Cancer biology Spinal cord injury or other types of tissue injury
Selected publications from our group:
- The evolutionarily conserved Arginyltransferase1 mediates a pVHL-independent oxygen sensing pathway in mammalian cells. Developmental Cell 2022 Mar 14;57(5):654-669.e9. (Cover Article)
- Regulation of mitochondrial respiratory chain complex levels, organization and function by arginyltransferase 1. Frontiers in Cell & Developmental Biology (2020) 8:603688.
- Reduced Arginyltransferase 1 is a driver and a potential prognostic indicator of prostate cancer metastasis. Oncogene. 2019 Feb;38(6):838-851.
- A rapid and precise mutation-activated fluorescence reporter for analyzing acute mutagenesis frequency. Cell Chem Biol 2018 Aug 16;25(8):1038-1049.e5.
- Posttranslational arginylation enzyme Ate1 affects DNA mutagenesis by regulating stress response. Cell Death and Disease (2016) 7, e2378;
Expected starting date: August 1- Dec1, 2022
Pay scale: We follows the NIH guideline for postdoc with starting salary for fresh PhD as $54,835 (increasing with experience). Highly qualified candidates with extensive experience will be considered for the position of assistant scientist with higher pay scale. The city of Miami has no state tax or city tax for income.
Contact of the PI (Fangliang Zhang, PhD): Fzhang2@miami.edu.
Links for job application for the postdoc and the assistant scientist positions: