The overall focus of the Charles lab is to decrease the global burden of mucosal and enteric infections of import affecting resource-poor and marginalized populations. More specifically, it involves the application of high-trough proteomic and genomic technologies to further our understanding of host-pathogen and immune responses during human infection by V. cholerae (the cause of cholera) and Salmonella enterica serovar Typhi and Paratyphi A (the primary cause of enteric fever) and to identify immunogenic antigens or molecular signatures for vaccine and diagnostic assay development. Research in the lab utilizes human patient samples in addition to using tumor cell lines to perform a variety of immunological, functional, and genome-scale assays to address 1) fundamental questions about protective immunity during human infection with S. Typhi or V. cholerae 2) the novel mechanisms these pathogens utilize to cause infection and 3) develop rapid diagnostic and seroepidemiological tools that can be used in resource-limited settings.
The ideal candidate will be a highly motivated molecular biologist and/or immunologist; have a PhD and/or MD degree; a strong background in microbiology, molecular and cellular biology, and/or immunology; and publications in peer-reviewed journals. Experience with next generation sequencing techniques and/or flow cytometry is desirable, but not necessary.
Successful candidates must be able to work in a highly collaborative environment, have high professional and ethical standards, demonstrate initiative, and have the ability to work under pressure and within short time constraints.
Send your resume, cover letter, and contact information for three references to Dr. Richelle Charles (firstname.lastname@example.org). Unfortunately, due to the number of applications we receive, we may not be able to reply individually to all inquiries.