英国利兹大学博士后职位—靶向给药的蛋白质化学

Research Fellow in Protein Chemistry for Targeted Drug DeliveryUniversity of Leeds

Description

Working closely with a second research fellow in the School of Physics & Astronomy, you will join a multidisciplinary team based in the Schools of Chemistry, Physics & Astronomy, Medicine and Electronic Engineering (Prof Bruce Turnbull, Prof Steve Evans, Dr Zhan Ong, Dr Jon Sandoe and Prof Steve Freear) to work on an EPSRC funded project to develop the use of microbubbles for targeting and treatment of microbial biofilm infections.

Antibiotics are becoming less effective because of resistance developed by bacteria. We aim to combat antibiotic resistance by developing better antibiotics as well as improving the way we use existing ones. In this project we will use microbubbles, similar to those already used as ultrasound scanning contrast agents, to deliver antibiotics directly to a site of infection. You will develop methods to conjugate the bubbles to proteins that target bacterial biofilms and assess their molecular targeting activity in microfluidic systems under flow conditions. You will investigate if combinations of molecular targeting proteins improve biofilm targeting. You will also perform experiments to load liposomes with antimicrobial peptides, and attach them to the microbubbles. You will perform drug release studies to investigate if the combined use of targeted microbubbles and ultrasound drug release methods can provide enhanced antibiotic efficiency.

To explore the post further or for any queries you may have, please contact:

Professor Bruce Turnbull

Tel: +44 (0)113 343 7438

Email: w.b.turnbull@leeds.ac.uk