Lerner Research Institute, Cleveland Clinic
Name of contact person for this position: Dr.Jianjun Wu
Email address of contact person: WUJ9@ccf.org
Institute: Cleveland Clinic Lerner Research Institute
Job Title: postdoctoral fellow
Overview / Keywords (max. 200 characters): Innate immunity, STING biology; T cell biology, molecular/cellular biology, molecular mechanism of innate immunity in inflammatory disease and cancer
Job Description (max. 100000 characters):
We are currently seeking highly motivated Postdoc Fellows to join our research team in the Center for Immunotherapy & Precision Immuno-Oncology at Cleveland Clinic Lerner Research Institute. Our research focuses on understanding the molecular mechanisms of innate immunity in inflammation and caner. Projects will involve using multidisciplinary approaches, including immunology, molecular biology, biochemistry, bioinformatics, and mouse models, to study innate immune response in cancer, with an ultimate goal of harnessing innate immunity to remodel tumor microenvironment for better cancer immunotherapy. The current projects are conceptually unique with solid preliminary data behind. The ideal candidates should have a PhD and/or MD degree and have a strong background and/or interest in innate immunity or cancer immunology. Proficient laboratory skills and a highly self-motivation are required. Applicants with experiences in immunology and mouse models are preferred. For interested candidates, please learn about our research from our recent publications.
· Wu, J., Dobbs, N., Yang, K., and Yan, N. (2020). Interferon-Independent Activities of Mammalian STING Mediate Antiviral Response and Tumor Immune Evasion. Immunity 53, 115-126 e115.
· Wu, J., Chen, Y.J., Dobbs, N., Sakai, T., Liou, J., Miner, J.J., and Yan, N. (2019). STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death. J Exp Med 216, 867-883.
· Wu, J.J., Li, W., Shao, Y., Avey, D., Fu, B., Gillen, J., Hand, T., Ma, S., Liu, X., Miley, W., et al. (2015). Inhibition of cGAS DNA Sensing by a Herpesvirus Virion Protein. Cell Host Microbe 18, 333-344.
· Wu J, Yan N. No Longer A One-Trick Pony: STING Signaling Activity Beyond Interferon. J Mol Biol. 2021:167257.
· Chu TT, Tu X, Yang K, Wu J, Repa JJ, Yan N. Tonic prime-boost of STING signalling mediates Niemann-Pick disease type C. Nature. 2021;596:570-5.
– Project design with the goal of data generation, analysis, interpretation
– Conducts research focused on Innate Immunity & Cancer Immunology
– Prepare manuscripts for publication, presentation and future research
– Plans, organizes, performs and monitors daily project protocols
PhD in an appropriate scientific field such as Molecular biology, Immunology, Microbiology, Cell biology, Biochemistry, or other similar science major.
COMPLEXITY OF WORK:
Requires critical thinking skills, decisive judgment, and work under supervision of the principle investigator. Full applications including curriculum vitae, a summary of current and future research interests and expected availability date, and three references should be submitted to: Jianjun Wu, PhD. E-mail: WUJ9@ccf.org