Funded post-doctoral positions are available in the Shen laboratory at Columbia University Irving Medical Center to investigate the molecular mechanisms of genitourinary development and tumorigenesis. We are a dynamic, highly-collaborative group that investigates research topics at the interface of developmental, stem cell, and cancer biology (https://www.genetics.cuimc.columbia.edu/research-labs/shen-lab). We are seeking highly-motivated applicants with a commitment to excellence for studies in the following areas:
1) Genitourinary organogenesis, stem/progenitor cells, and lineage specification. We use genetically-engineered mouse models. single-cell analyses, and systems biology approaches to understand development, regeneration, and repair of the urogenital system, focusing on the prostate. (Wang et al. (2009) Nature 461: 495-500 PMID: 19741607; Talos et al. (2017) Nat. Comm. 8: 14662 PMID: 28429718; Shibata et al. (2020) Stem Cell Rep. 15: 1026-1036 PMID 33176121; Crowley et al. (2020) eLife 9: e59465 PMID 32915138)
2) Prostate cancer initiation, progression, and castration-resistance. We use mouse models, organoid culture, and human tissue samples to elucidate cell types of origin as well as molecular mechanisms of prostate tumorigenesis (Wang et al. (2013) Nat. Cell Biol. 15: 274-283 PMID: 23434823; Wang et al. (2014) Cell Rep. 8: 1339-1346 PMID: 25176651; Chua et al. (2014) Nat. Cell Biol. 16: 951-961 PMID 25241035; Zou et al. (2017) Cancer Discov. 7: 736-749 PMID 28411207; Chua et al. (2018) eLife 7: e28768 PMID: 29334357)
3) Molecular mechanisms of bladder cancer. We use human patient-derived organoid and xenograft models to analyze clonal evolution, drug response, and metastasis in bladder cancer (Lee et al. (2018) Cell 173: 515-528 PMID: 29625057)
Interested candidates should have a Ph.D. degree with a strong background in stem cell biology, developmental biology, and/or cancer research. Expertise with mouse models, organoid culture, imaging, single-cell sequencing, and/or computational biology would be advantageous.
To apply, please send a CV together with a description of research experience and interests, as well as the names of three references to:
Michael M. Shen, Ph.D.
Arthur J. Antenucci Professor of Medical Sciences
Professor of Genetics & Development, Urology, and Systems Biology
Columbia University Irving Medical Center
Herbert Irving Comprehensive Cancer Center
1130 St. Nicholas Ave, room 217B
New York, NY 10032
Columbia University is an Equal Opportunity Employer/Disability/Veteran.