Postdoctoral Scientist-human iPSCs/cardiovascular development (The Zhao Lab, Center for Cardiovascular Research)
A postdoctoral scientist position is immediately available in Dr. Mingtao Zhao’s laboratory in the Center for Cardiovascular Research at the Nationwide Children’s Hospital and The Ohio State University in Columbus, Ohio. The Zhao lab is using patient-derived induced pluripotent stem cells (iPSCs), CRISPR/Cas9 genome editing, and single-cell genomics to study the molecular and genetic mechanisms of cardiovascular development and congenital heart disease (PNAS 2017, PMID: 29203658; Circ Res 2017, PMID: 29030344; Stem Cells 2020, PMID: 32232889, Front Cell Dev Biol 2021, PMID: 33585486). The goal of the Zhao lab is to elucidate the cause-consequence relationship of a given genetic variant in regulatory elements (such as enhancers) in the contribution of cardiovascular disease using patient-specific iPSCs that retain all genetic information of the affected patients. The Zhao lab is currently funded by NIH/NHLBI, Additional Ventures, AHA, and Abigail Wexner Research Institute at Nationwide Children’s Hospital.
This is a great opportunity for young investigators who aim to establish an independent academic career in the next few years. Successful candidates should have a PhD/MD or equivalent degree (< 3 years after graduation) and should have solid expertise in cardiac physiology, cardiovascular development, or organoid biology. Candidates who have additional expertise in bioinformatics or CRISPR/Cas9 genome editing or tissue engineering would be preferred.
The Center for Cardiovascular Research currently has a NIH-funded T32 postdoctoral program to provide interdisciplinary, translational, and state-of-the-art research training in congenital and acquired heart disease, partnered with The Ohio State University College of Medicine. The Abigail Wexner Research Institute is one of the largest pediatric research centers and consistently ranked among the top 10 for NIH funding among free-standing children’s hospitals in the United States. In addition, Nationwide Children’s Hospital has been consistently ranked on the US News & World Report’s “America’s Best Children’s Hospitals Honor Roll”.
What Will You Be Doing?
- Performing cardiac differentiation and organoid induction
- Design and conduct scientific experiments to obtain data
- Write and publish scientific manuscripts
- Contribute to grant submissions for external funding
Obtain postdoctoral fellowship and career development award from the AHA and/or
What Are We Looking For?
To fulfill this role successfully, you must possess these minimum qualifications and experience:
- PhD. or equivalent doctorate in Cell/Molecular/Developmental Biology, Cardiovascular Physiology, Genomics or related field
- Desire to pursue a career in biomedical research
- Knowledge of the research process.
- Necessary technical skills in the appropriate area of research.
- Ability to do technical writing and good communication skills.
Minimum Physical Requirements:
Percent of time spent on:
25% Designing and developing protocols
25% Performing research work
25% Recording and analyzing data generated by research study
10% Writing grant proposals
10% Preparing scientific and technical papers
03% Liaison with OSU researchers
02% Miscellaneous paperwork associated with research
Potential candidates should send their CV (with publication list) and Cover Letter describing future research vision to
Mingtao Zhao, PhD
Center for Cardiovascular Research
Nationwide Children’s Hospital
Departments of Pediatrics
The Ohio State University College of Medicine