Postdoc in Functional Cancer Genomics
Position: Postdoc in Functional Cancer Genomics
Department: Applied Functional Genomics
Code number: 2022-0085
The German Cancer Research Center is the largest biomedical research institution in Germany. With more than 3,000 employees, we operate an extensive scientific program in the field of cancer research.
The laboratory of Prof. Dr. Claudia Scholl (Division of Applied Functional Genomics) at the German Cancer Research Center (DKFZ) in Heidelberg is interested in finding and characterizing specific molecular alterations and associated vulnerabilities in cancer cells that can be exploited for the development of targeted therapies. In particular, our mission is to improve the understanding of sarcomas and other rare cancers, as we often lack insight into the biology of these diseases, ultimately leading to few treatment options for affected patients.
The postdoctoral researcher will work as part of an interdisciplinary team of scientists to functionally characterize previously unrecognized recurrent genetic alterations that have been discovered in the MASTER (Molecularly Aided Stratification for Tumor Eradication) Program of DKFZ, the National Center for Tumor Diseases, and the German Cancer Consortium, one of the most comprehensive precision oncology programs worldwide, with which we collaborate very closely. The successful candidate will generate cellular models representing the entities carrying molecular profiles of interest, examine the resulting phenotypes, establish in vivo disease models where appropriate, and analyze the impact of genetic alterations on biological processes. The methods used (in addition to standard molecular biology, cellular, and protein biochemistry methods) include, e.g., CRISPR and other lentiviral gene manipulations, next-generation sequencing, automated microscopy, and mechanism-directed analyses.
We are looking for an early-career scientist who is highly motivated, ambitious, and commited to experimental cancer research. The candidate should be able to work independently and also have excellent teamwork skills. Applicants must hold a Ph.D. in biology, biochemistry, biotechnology, or a related field, and have published previously in international peer-reviewed journals. Expertise in molecular and cellular biology, with specific focus on genome engineering techniques is advantageous. Profound knowledge of cancer biology, strong communication skills, and excellent written and oral command of English are required.
The application should include a curriculum vitae, a motivation letter, degree certificates, the expected availability date, a complete list of publications, and the names and contact information of at least two references.
Interesting, versatile workplace
International, attractive working environment
Campus with modern state-of-the-art infrastructure
Salary according to TV-L including social benefits
Possibility to work part-time
Flexible working hours
Comprehensive further training program
Access to the DKFZ International Postdoc Program
The DKFZ is subject to the regulations of the Infection Protection Act (IfSG). As a consequence, only persons who present proof of immunity against measles as well as against COVID-19 may work at the DKFZ.
Earliest possible start date: as soon as possible
Duration: The position is limited to 2 years.
The position can in principle be part-time.
Application deadline: 23.03.2022