宾夕法尼亚州立大学博士后职位招聘—神经外科

Neuroscience Research at Penn State University, Pennsylvania, USA

Job description: Postdoctoral position is available immediately to investigate the cellular and molecular mechanisms of neurological dysfunction after acute ischemic stroke and traumatic brain injury (TBI), with the ultimate goal of developing novel therapeutic strategies. In particular, we aim to study the mechanisms underlying aberrant endoplasmic reticulum (ER) stress, dysfunction of autophagy and lysosomal pathway, and dysregulation of cell-cell interactions between CNS neurons, microglia, and astrocytes, and their contribution to neuroinflammation and neuro-immune dysfunction in both stroke and TBI pathology. Combined approaches including experimental models of stroke and TBI, cell cultures (in vitro BBB/TBI model), behavioral tests, advanced brain imaging (3D MRI, confocal laser-scanning microscope), immunohistochemistry, flow cytometry, neurovascular biology, and molecular biology are employed.

Job requirements: Applicants should have a Ph.D. (or M.D.) in Basic Science, Biomedical Science, or a related field, and a record of publication success. Experience in neuroscience research, conditional knock‐out mice, CRISPR‐CAS9‐based gene editing, and performing MCAO and TBI models is preferred. Candidates should be highly motivated and quick learner to learn new research technology and have strong oral and written communication ability and good organizational skills.

Please attach to your job application and send letter of interest, your contact information, CV, and the name and email address of 2-3 references to: Dr. Guohong Li

(gul48psu.edu; guohonglipennstatehealth.psu.edu).

Penn State is a top-ranked research university and Pennsylvania’s sole land-grant institution, founded with a mission of high-quality teaching, expert research, and global service.

Penn State is an Equal Opportunity/Affirmative Action/Equal Access Employer.

Penn State requires all faculty, staff, and students to be vaccinated against COVID‐19. Exemptions for medical or religious reasons will be processed through Human Resources.

Representative publications from Dr Li’s lab:

Stroke. 2017;48(12):3356‐3365. A study of CD147 in post‐stroke thrombo‐inflammation.

Stroke. 2018;49(7):1708‐1718. A study of taurine in tPA‐combination stroke therapy.

Hypertension. 2019;73(1):206‐216. A study of PI3Kg in tPA‐combination stroke therapy

Brain Behav Immun. 2019;82:13‐24. A study of CD147 in WM damage and cognitive deficits.

J Neuroinflammation. 2019;16(1):198. A study of CD147 in stroke‐associated pneumonia.

Neurotherapeutics. 2019;16:1320‐1334. A study of PI3Kg in neuronal ER stress after TBI.

Exp Neurol. 2019; 314:20‐33. A study of EPPS in neuronal autophagy after TBI.

Experimental models well established in Dr. Li’s lab

Stroke models in both mice and rats:

Suture MCAO/reperfusion (induced by suture withdrawal)

Embolic MCAO/reperfusion (induced by IV rtPA)

TBI models in both mice and rats: Controlled cortical impact (CCI)

Ischemic carotid artery disease/stenosis model in mice

This is a limited-term appointment funded for one year from date of hire, with possibility of refunding.

Employment will require successful completion of background check(s) in accordance with University policies.

The Pennsylvania State University is committed to and accountable for advancing diversity, equity, and inclusion in all of its forms. We embrace individual uniqueness, foster a culture of inclusive excellence that supports both broad and specific diversity initiatives, leverage the educational and institutional benefits of diversity, and engage all individuals to help them thrive. We value inclusive excellence as a core strength and an essential element of our public service mission.

Apply online at https://apptrkr.com/2859054

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Penn State is an equal opportunity, affirmative action employer, and is committed to providing employment opportunities to all qualified applicants without regard to race, color, religion, age, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.