A postdoctoral position is immediately available in the Barbieri laboratory to study the molecular mechanisms regulating neuroblastoma cell metabolism. The laboratory, funded by NCI, is currently focused on the study of how MYCN, which drives neuroblastoma initiation and treatment resistance, interacts with specific components of the molecular clock to rewire cell metabolism and drive oncogenesis, with particular emphasis on cell metabolism, circadian metabolic oscillation, and differentiation. The candidate will use a combination of various cell and molecular biology approaches (including CRISPR-Cas9 gene editing, RNA-seq, ChIP-seq, metabolomics and metabolic tracing), as well as different tumors models (transgenic, xenograft/PDX, and syngeneic) to explore the regulation of tumor metabolism induced by MYCN during neuroblastoma initiation and progression.
- Designs and performs experimental studies that directly answer the above research questions, using both in vitro systems and animal models (with the supervision of the PI).
- Collects and analyzes data and presents at national/international conferences/meetings.
- Prepares manuscripts for publication.
- Applies for external fellowships.
- Mentors junior lab members.
- MD or Ph.D. in Basic Science, Health Science, or a related field.
- No experience required.
- Ph.D. degree.
- Prior first author publications.
- Strong background in cancer biology, cell and molecular biology, and mouse models of cancer. Candidates should be highly motivated to pursue an independent career in biomedical research.
- Background in cancer cell metabolism.
Baylor College of Medicine requires employees to be fully vaccinated -subject to approved exemptions-against vaccine-preventable diseases including, but not limited to, COVID-19 and influenza.
Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.