Postdoctoral Scholar – Botchan Lab – Department Of Molecular & Cell Biology
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Molecular & Cell Biology / College of Letters & Science – Biological Sciences / UC Berkeley
Position title: Postdoctoral Scholar
Salary range: $54,540 to $63,036
Percent time: 100%
Anticipated start: January 2022
Position duration: 2 years with possibility of extension
Open date: December 13th, 2021
Next review date: Tuesday, Dec 28, 2021 at 11:59pm (Pacific Time) Apply by this date to ensure full consideration by the committee.
Final date: Wednesday, Jan 12, 2022 at 11:59pm (Pacific Time) Applications will continue to be accepted until this date, but those received after the review date will only be considered if the position has not yet been filled.
The Botchan Lab seeks candidates for appointment as postdoctoral scholar to join our project: Studies to Explore DNA Replication Proteins in Functional Assemblies through Intrinsically Disordered Domains. The Botchan Lab studies the study the mechanisms and regulation of the initiation of DNA replication in eukaryotes and how this process is coupled to the cell cycle. Drosophila melanogaster provides us with a unique metazoan model for this study as we have a genetic handle to readily test discoveries from biochemistry and structural biology. The primary objective of this project is the evaluation how intrinsically disordered regions are used to manifest phase-separated compartments or protein/nucleic- acid clustering for functional purposes. Initiator proteins ORC, CTD1 and Cdc6 all phase separate from bulk solutions in test tubes and are recruited to chromosomes in anaphase where such molecular attributes seem critical. In particular the ORC1 IDR is essential for DNA replication. ORC is also present in drosophila and human heterochromatin compartments with HP1 in G1 and S phases. How this interaction is mediated and for what ends will be a major goal.
Basic qualifications (required at time of application)
Candidates must hold a Ph.D. or equivalent international degree or be in the process of obtaining a Ph.D. or equivalent international degree at the time of application.
Additional qualifications (required at time of start)
Candidates must have obtained their Ph.D. or equivalent international degree by the start date of the job. No more than 4 years of experience in the postdoc title by the start date of the job.
Demonstrated ability to attain a high level of achievement as an independent researcher. Ability to work with team members to accomplish goals. Excellent written and oral communication skills. Ability to construct recombinant vectors for expression in TC and some experience in imaging tagged proteins.
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Statement of Research
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