Postdoctoral Research Scholar
Molecular Mechanisms of Hedgehog Signaling in the
Development, Cancer and Metabolism
Markey Cancer Center, University of Kentucky, Lexington, KY
Overview: The University of Kentucky Markey Cancer Center (MCC) is proud to be Kentucky’s only National Cancer Institute-designated cancer center located in beautiful Lexington, Kentucky. The University of Kentucky is one of only a few universities in the country to have its undergraduate, medical and graduate colleges (16 total) and a nationally-recognized medical center and hospital on one central campus which allows for unique multidisciplinary collaborations. The MCC, consistently ranked in the top 50 cancer centers in the country by US News and World Report, is dedicated to driving a measurable reduction in cancer incidence and mortality in Kentucky through a comprehensive program of cancer research, prevention, community outreach, education and patient care.
We are currently recruiting an outstanding and ambitious postdoctoral research scholar to work with our team of talented multidisciplinary investigators. Our projects focus on developmental biology, cancer biology, and cell biology on studies of the molecular mechanisms of Hedgehog signaling in development and other novel mechanisms involved in lipid and glucose metabolism.
The goal of our research is to understand the molecular mechanisms of the Hedgehog (Hh) signaling, which governs the pattern formation, cell proliferation and differentiation. Malfunction of Hh signaling induces different types of cancers. The study in our laboratory focuses on how Hh signaling is involved in development, cancer, and metabolism.
Hh pathway consists of two transmembrane proteins, Patched (Ptc) and Smoothened (Smo), and a zinc-finger transcription factor, Cubitus interruptus (Ci), that transduces Hh signal into the nuclei. Without Hh stimulation, Ptc inhibits Smo thus allowing Ci processing to generate its truncated form which enters the nuclei and blocks downstream genes. Upon Hh stimulation, the inhibition of Ptc on Smo is blocked and Smo transduces the Hh signal to downstream blocking Ci processing. Full-length Ci is translocated to the nuclear and turns on downstream genes. We are investigating the mechanisms of how Smo is activated in response to Hh stimulation and how Hh gradient can be translated into different thresholds of downstream gene expression.
Our lab is housed in the newly constructed Healthy Kentucky Research Building (HKRB). This is a wonderful opportunity for the successful candidate to interact with talented young scientists in an excellent research environment. The position is open to individuals with an interest in demonstrated records in biochemistry, cell biology, or developmental biology related to cancer research. Salary will be based on experience.
To apply please submit your complete application at https://ukjobs.uky.edu/postings/364733 (DU08595). You must include the contact information for three references on your application and upload a cover letter, CV and your PhD transcript.
The University of Kentucky is an Equal Opportunity University that values diversity and inclusion. Individuals with disabilities, minorities, veterans, women, and members of other underrepresented groups are encouraged to apply.