Institute for Systems Biology (ISB)
Institute for Systems Biology (ISB) is seeking highly-motivated postdoctoral candidates in the areas of cancer biology and immuno-oncology. The Postdoctoral Fellow will work, under the supervision of Drs. Heath and Wei, on several fundamental and technological challenges associated with advancing personalized TCR-engineered cancer immunotherapies. They are expected to leverage an innovative set of bioengineered molecules and technical tools to build a high-throughput, low-bias approach for identifying Class I and Class II truncal neoantigens, the cognate TCR sequences, and the anti-tumor functional characteristics of those selective T cells with the goal to develop a discovery-based approach in which the TCRa/ß genes, the neoantigens, and the MHC alleles are all identified in one experiment, using a simple blood draw.
Candidates should have a Ph.D. in Biology, Biological or Biomedical Engineering, Chemistry, or other related areas. They should have demonstrated the ability or potential to conduct interdisciplinary research with good communication skills and a strong publication record. Candidates with research experiences in cancer immunology, cancer biotechnology and/or single-cell technologies and computational methods are strongly preferred. Please visit https://heath.isbscience.org/ and http://wei.systemsbiology.org for more information about the labs.
Applicants should submit a curriculum vitae and 1-page description of research interest/plan along with the application.
ISB is an EOE (M/F/disability/minority/veteran status)
About the Institute for Systems Biology (ISB)
ISB is a collaborative and cross-disciplinary non-profit biomedical research institute based in Seattle WA, and focuses on some of the most pressing issues in human health, including brain health, cancer, sepsis ,and aging, as well as many chronic and infectious diseases. ISB currently hosts 12 research groups with expertise ranging across genetics, microbial genetics, complex molecular machines, macromolecular complexes, gene regulatory networks, immunology, molecular and cell biology, cancer biology, genomics, proteomics, protein chemistry, computational biology, and biotechnology. Unlike in traditional academic departments, our faculty are cross-disciplinary and work collaboratively toward a common vision. This cross-disciplinary approach enables us to take on big, complex problems.
ISB was created by genomics pioneer Dr. Leroy Hood in 2000 as the first-of-its-kind institute dedicated to systems biology. ISB is in the top ranks of scientific institutions worldwide. In 2012, the SCImago ranked ISB 4th worldwide on its Excellence Rate scale. ISB strives for a culture of academic excellence and champions sound scientific research that has real-world translational impact. ISB faculty members have launched several successful companies, including: Cytopeia (acquired by BD in 2008), Integrated Diagnostics, Macrogenics, NanoString Technologies, PACT Pharma, Isoplexis, Sofie Biosciences, and Accelerator Corporation. ISB is an affiliate of Providence St. Joseph Health, one of the largest not-for-profit health care systems in the United States