The University of Virginia Department of Cell Biology seeks a postdoctoral research associate in the Laurie Lab. A newly minted postdoctoral research associate is sought for systematic screening of lacritin benefits in neurodegenerative diseases, and then to work out mechanisms by CRISPR/Cas 9 gene editing and shRNA coupled with protein biochemistry, mutant analysis, C. elegans modeling, and potentially super resolution microscopy. This project builds on preliminary studies with IPSC-derived human neurons.
Lacritin was identified and named by us (Sanghi et al, J Mol Biol ‘01). Subsequent characterization studies (including J Cell Biol ’06a; J Cell Biol ’06b; J Biol Chem ’13a; J Biol Chem ’13b; J Biol Chem ’21) have realized its fundamental role in promoting and restoring homeostasis in health and disease leading to the founding of two companies – one now with a successfully completed phase 2 trial, and with FDA approval for two phase III trials. The research associate will join the collaborative multi-institutional ’Lacritin Consortium’ founded in 2002.
The Consortium of graduate and undergraduate students, technicians and faculty from 13 different institutions meets and shares data. The lab is supported by two NIH R01 grants through to 2026. For 2022, the University was ranked the No. 4 best public university and #25 overall by U.S. News and World Report.
The successful applicant will be ideally seeking their first Postdoctoral position, have qualifications appropriate for independent NIH postdoctoral funding, and have published in excellent journals. If interested, please contact Gordon Laurie, PhD with CV/resume, a cover letter and three references.
Also, please apply through ‘UVA Workday’ by searching for R0029065 and complete the online application online (for questions about and assistance with the application process, please contact Margaret Weeks, Academic Recruiter).