POSTDOCTORAL POSITION ON “COMBINATORIAL, HIGH-THROUGHPUT ORGANOID SCREENS FOR PERSONALIZED MEDICINE”
Last modification : Wednesday, October 13, 2021
The Division of Mechatronics, Biostatistics and Sensors (MeBioS) performs groundbreaking research on innovative sensor technologies and the associated data analysis methods to understand and control the quality of products and ongoing processes. The Biomimetics research group focuses on replicating biological functions via engineered micro- and nano-systems for biomedical applications.
Recent years have seen a surge in the development of microfluidicplatforms for a wide diversity of applications, from diagnostics to newfundamental science studies. Microdroplet-based platforms (a particular branchof microfluidics capable of generating and manipulating identical, fL tonL-sized droplets at kHz rates) has spearheaded several revolutionaryHigh-Throughput Screening (HTS) assays, notably for applications in single cellomics. Yet, other promising HTS applications of droplet-based microfluidics(such as drug screening) remain largely untapped due to the impossibility ofcurrent droplet generation strategies to handle drug libraries in acombinatorial manner.
The first phase of this project aims to develop astrategy to solve the aforementioned limitation of droplet-based technology bydeveloping a hybrid microfluidic-liquid handling platform with the capacity ofgenerating large droplet libraries with distinct chemical payloads. Your taskswill involve:
• Designing, manufacturing and testing of novelmicrofluidic devices capable of rapid and multiplexed droplet formation.
• Testing and applying amelioration strategies forstable long-term droplet storage and prevention of payload leakage / dropletcross-talk.
• Setting up and operation of droplet screeningsystems and lab automation devices (e.g. liquid handling systems).
In the second phase of this project you will adaptthis platform to enable the production of/experimentation with patient-derivedorganoids, with the aim of screening and selecting optimal combinatorialtreatments for Cystic Fibrosis (CF) patients not eligible for registeredmodulator treatments (which currently comprise 10% of the ofthe total population of CF patients)
Are you an energetic person, able to both think critically and creatively in scientific terms while also being effective at overcoming technical challenges? Are you keen on working at the crossroads of several disciplines (from engineering to biomedicine)? Then you may be the perfect scientist to join our team.
The ideal candidate will possess the following skillset:
•Expert knowledge of microfluidic technologies, ideally with a strong focus on droplet-based techniques.
•Robust experience in spectroscopic techniques (specially fluorescence strategies for multicolor imaging).
•Applied knowledge of molecular cell biology techniques.
•Experience in developing automated control systems and programming (in either Matlab, Python or C++).
Important: to be eligible, candidates must not have been engaged in a principal activity (work, studies, etc.) in Belgium for more than 24 months in the last 3 years.
•We offer a full-time Postdoctoral position for 1 year. After positive evaluation, the contract can be extended to 2 additional years (3 years in total).
•State of the art research infrastructure.
•A challenging job in a young, dynamic environment.
•High level scientific training at a top-ranked university.
•Excellent guidance by our young, dynamic and multidisciplinary team.
•Being part of a world-class research group.
•Remuneration according to the KU Leuven salary scales (https://www.kuleuven.be/english/research/associatienet/postdoc).
For more information please contact Prof. dr. Xevi Casadevall i Solvas, tel.: +32 16 37 71 03, mail: firstname.lastname@example.org.
You can apply for this job no later than December 15, 2021 via the online application tool
KU Leuven seeks to foster an environment where all talents can flourish, regardless of gender, age, cultural background, nationality or impairments. If you have any questions relating to accessibility or support, please contact us at diversiteit.HR@kuleuven.be.
Please also have a look at our other opportunity: https://www.kuleuven.be/personeel/jobsite/jobs/60068505?hl=en&lang=en