Howard Hughes Medical Institute (HHMI)
Postdoctoral Associate – Scientific Software Programming
We are currently looking for a highly skilled Postdoctoral Associate – Scientific Software Programming to develop software for computational biological image analysis and work as a team member in Dr. Tamir Gonen’s lab in UCLA’s Department of Biological Chemistry. The Gonen lab works toward understanding how membrane proteins help cells maintain homeostasis. To that end, they study channels, transporters, and receptors structurally and functionally. More information about the lab can be found by visiting https://cryoem.ucla.edu/
The chosen candidate will work with a multidisciplinary team which includes computational scientists, biophysicists, biochemists, and cryo-EM specialists to develop a software package for biological structure determination using image analysis of biological electron diffraction patterns. The chosen candidate will work with co-investigators to tailor analyses for their individual manuscripts for peer-review submission, including electronic literature review. This software will become a part of MicroED technique developed by the Gonen laboratory.
Develop a software package for image analysis of biological diffraction patterns.
•Prototype modules of the system using Python and numpy.
•Implement and optimize the code using C++.
•Integrate developed modules with the software package.
•Develop conda installer for the software package.
Write code documentation.
•Write in-line documentation for each software module specifying input, output, and function performed.
•Develop web-based documentation for the package that will contain list of modules, description of their respective functionalities, and specified relation between them.
Write software package user manual.
•Develop interactive web-based manual for the software package.
•Consult with the members of the group as for the expectations and requirements.
•Provide test data sets to accompany the manual.
•Publish results in peer reviewed journals and online depositories.
Education and Experience
•PhD in physics, computational biology, chemistry, biochemistry, mathematics or a related field is required.
Knowledge, Skills, and Abilities
•Knowledge of multivariate statistics, diffraction theory and imaging issues, research design, and survey/questionnaire development is required.
•Strong proficiency in Python, C, C++, image analysis, and format conversions is required.
•Ability to work well both independently and as part of a team.
•Ability to remain technologically current within the scope of the role.
•Strong written and verbal communication skills.
•Strong organizational, time management, and prioritization skills.
•Strong attention to detail with a high degree of accuracy.
Remaining in a normal seated or standing position for extended periods of time; reaching and grasping by extending hand(s) or arm(s); dexterity to manipulate objects with fingers, for example using a keyboard; communication skills using the spoken word; ability to see and hear within normal parameters; ability to move about workspace. The position requires mobility, including the ability to move materials weighing up to several pounds (such as a laptop computer or tablet).
Persons with disabilities may be able to perform the essential duties of this position with reasonable accommodation. Requests for reasonable accommodation will be evaluated on an individual basis.
This job description sets forth the job’s principal duties, responsibilities, and requirements; it should not be construed as an exhaustive statement, however. Unless they begin with the word “may,” the Essential Duties and Responsibilities described above are “essential functions” of the job, as defined by the Americans with Disabilities Act.