UK Research and Innovation
Postdoctoral Scientist/ CDF
Salary Range £32,302 to £35,143 per annum
Fixed term 3 years
MRC Laboratory of Molecular Biology, Cambridge, UK
The MRC Laboratory of Molecular Biology is a world leader in biological research, with an expanding scientific programme dedicated to understanding gene function in health and disease. It provides an unsurpassed environment for both young and established researchers. Scientists are drawn to the LMB from all over the world, creating a lively and international community for the exchange of ideas and technical innovation.
Applications are invited for a Postdoctoral Scientist to join Dr Michael Hastings’ multidisciplinary research group to investigate the molecular neurobiology of circatidal time-keeping in the marine isopod crustacean, Eurydice pulchra. A great diversity and abundance of life inhabits environments that vary over tidal/lunar time. Such organisms have, therefore, evolved circatidal biological clocks that drive tidal and lunar rhythms of behaviour and metabolism that adapt them to their cyclical world. Absolutely nothing is known of the molecular neurobiology of such tidal clocks: this rich neurobiological problem is virgin territory. The project will utilise next generation RNA-sequencing, genomic analyses, homology cloning, behavioural analyses, protein expression and neurobiological examination and manipulation of the Eurydice nervous system to characterise the molecular genetics behind this elusive clock. The Applicant will be well supported by the extensive resources and expertise of LMB, with close collaboration with internal and external groups.
Candidates should be expert in transcriptome bioinformatics and molecular genetics, including RNA extraction, PCR, DNA cloning, genomic sequence analysis etc. Expertise in protein biochemistry, immunohistochemistry and in situ hybridisation alongside a general interest in neurobiology are highly desirable. We shall identify tidally regulated genes, define their regulatory genomic elements and then determine the functions of their encoded proteins in cell culture and in vivo. Is the tidal clock a shorter cycle equivalent of the well-known circadian feedback loop, or is it something more exotic? How does its architecture compare with other non-circadian oscillators?
The successful applicant will be awarded a 3-year Career Development Fellowship/ Postdoctoral Training Scheme position. This is a training and development position for a Postdoctoral Scientist who has recently completed their doctoral studies, is moving into a new research discipline or has limited experience of key transferable skills. The MRC LMB has excellent scientific core facilities and training opportunities.
The MRC Laboratory of Molecular Biology is a research institute within UK Research and Innovation (UKRI). UKRI is an entity that brings together nine partners to create an independent organisation with a strong voice for research and innovation, more information can be found at www.ukri.org.
Working for UKRI MRC provides a whole host of benefits including a defined benefit pension scheme, excellent holiday entitlement (40 ½ days including bank holidays and privilege days) and Benenden Healthcare membership. You will also have access to employee shopping/ travel discounts, on site sport and social facilities, as well as salary sacrifice cycle to work schemes and childcare vouchers.
To apply and access full details of the vacancy please visit our job board athttps://mrc.tal.net/vx/appcentre-int/candidate/post/3408/en-GB.
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