挪威奥斯陆大学微生物学/分子生物学方向博士后职位

Oslo universitetssykehus

A 2-Year Postdoctoral Fellow/Researcher Available

Department of Microbiology, Section for Research

Postdoctoral Fellow/Researcher (2-Year Initial) with capacity for extension available.

Investigating dynamic RNA and histone modifications in cancer stem cells

We are interested in the mechanisms of dynamic RNA plasticity / histone regulation and how these processes affect pluripotent and cancer stem cell biology. With recent pioneering work, the field of RNA regulation in oncogenesis is rapidly developing.

Tasks

This post will focus on characterizing novel mechanisms for gene regulation and the identification of underlying genes and enzymes. The successful candidate is capable of conceptual thinking, is looking forward to learning new techniques, has good communication skills and is well organized. Knowledge of basic methods in molecular biology (RNA and/or chromatin modification analyses), prostate cancer cell is highly advantageous. Required is experience with at least one of the following areas or tools: Crispr-Cas9 based genetic engineering, ChIP-Seq, real-time PCR, RNA-seq, microRNA biology, inducible knock-down/ over-expression systems.

Qualifications

The potential candidate must have completed a PhD degree in molecular biology or medicine, with one or several publications in internationally well-regarded, peer-reviewed scientific journals. Applicants with publications in press are also considered. Interested persons with aforementioned experience and skill set, should submit the following documents (note that applications lacking any of these three requirements will be terminated without further evaluation):

1) A concise application letter explaining your motivation for this position (1-2 pages).

2) Curriculum vitae including a list of peer-reviewed publications.

3) Contact information of three references.

Personal qualities

We are looking for an enthusiastic and determined individual who can work both independently as well as in a group setting.

Applications

1) A concise application letter explaining your motivation for this position (1-2 pages).

2) Curriculum vitae including a list of peer-reviewed publications.

3) Contact information of three references.

The postdoctoral position will commence fall 2021and will extend over a minimum of 2 years with an evaluation period of 6 months. A selection committee will announce the candidates two weeks after the closing deadline for interviews. Oslo University Hospital is an equal opportunity employer.

Relevant References

Reversible RNA modifications in meiosis and pluripotency. Klungland A, Dahl JA, Greggains G, Fedorcsak P, Filipczyk A. Nat Methods. 2017 Jan 29;14(1):18-22.

Filipczyk A, Marr C, Hastreiter S, Feigelman J, Schwarzfischer M, Hoppe PS, Loeffler D, Kokkaliaris KD, Endele M, Schauberger B, Hilsenbeck O, Skylaki S, Hasenauer J, Anastassiadis K, Theis FJ, Schroeder T. Network Plasticity of Pluripotency Transcription Factors in Embryonic Stem Cells. Nature Cell Biology, 2015:17:1235-46.

Filipczyk A, Gkatzis K, Fu J, Hoppe PS, Lickert H, Anastassiadis K, Schroeder T. Biallelic expression of Nanog protein in mouse embryonic stem cells. Cell Stem Cell, 2013:13:12-3.

Zheng, Dahl, Niu et al ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility. Mol Cell. 2013:49:18-29.