圣路易斯华盛顿大学医学院博士后职位招聘 圣路易斯华盛顿大学医学院博士后职位--神经科学、生物学、工程学、计算机科学、经济学或心理学 Monosov Laboratory https://neuroscience.wustl.edu/people/ilya-monosov-phd/ Several postdoctoral positions are available in the Monosov laboratory in the Department of Neuroscience at Washington University School of Medicine in St. Louis. By working with animals, humans, and computational models, our team aims to uncover the neuronal-basis of adaptive and maladaptive decision making, learning, and cognition, and to reverse engineer the complex internal states that give rise to psychiatric disorders. We are especially interested in the neurobiology of (i) risky decision-making under uncertainty, (ii) exploration and novelty-seeking, (iii) appetitive and aversive learning, and (iv) curiosity. We wish to discover how such sophisticated behaviors are controlled in health and disease. In terms of techniques, the laboratory combines cutting-edge large-scale neurophysiology, circuit-mapping, and causal circuit-disruption approaches in non-human primates and mice. We also regularly perform human behavioral experiments, and utilize computational methods, aiming to understand the algorithms agents employ to adaptively (or maladaptively) control cognitive behaviors. Modern neuroscience spans systems, computational, and molecular approaches. Therefore, to improve our chances of making important discoveries candidates with a wide range of skillsets will be considered. Particularly, successful candidates could have a PhD in neuroscience, biology, engineering, computer science, economics, or psychology. Passion and creativity are key qualities in applicants. Experience with behavioral task design and detailed behavioral analyses, programming, neurophysiology, optogenetics, or computational psychiatry / biology are welcome, but not necessary. Our laboratory is a part of several cross-institution collaborative Centers funded by the NIH and DOD. These projects include clinicians, engineers, and computational neuroscientists. To participate in these teams, we also encourage a collaborative spirit and a passion for learning new perspectives and viewpoints. Interested postdoc candidates should send a cover letter and curriculum vitae with contact information for three references to monosovi@wustl.edu and to ilya.monosov@gmail.com. Information on being a postdoc at Washington University can be found at https://postdoc.wustl.edu/prospective-postdocs-2/. EEO/AA Statement Washington University is an equal opportunity and affirmative action employer. All qualified applicants will receive consideration without regard to an individual’s sex, race, color, religion, age, disability status, protected veteran status, national or ethnic origin, gender identity or expression, sexual orientation. Women, minorities, protected veterans and the disabled are strongly encouraged to apply.

新西兰奥塔哥大学博士后职位招聘 新西兰奥塔哥大学博士后职位—化学 Postdoctoral Fellow - Chemistry-2200570 University of Otago Description The Department of Chemistry at the University of Otago is the oldest chemistry department in New Zealand. It has grown to be one of the largest Departments in the Division of Sciences and contributes to various courses and programmes in Sciences and Health Sciences. Responsibility for the Department's dual mandate of teaching and research is shared among full-time academic staff and a number of teaching and research fellows, assisted by a similar number of technical, secretarial and general staff. As such, the Department is one of the largest and most active in New Zealand, with working conditions and facilities that rival those of many overseas departments. The role/Te mahi The Royal Society of New Zealand Marsden Fund has awarded the Ennis group a 3-year research grant to investigate the formation and structure of nitrogenous co-crystal minerals relevant to Titan's atmosphere and surface; including the study of possible astrochemical pathways toward higher-order organic molecules. This postdoctoral research position is to support and advance all objectives of this laboratory astrochemistry research project, including the coordination of overseas experiments with expert collaborators at ANSTO Sydney and at NASA Jet Propulsion Laboratory. Key tasks of the role include: • Synthesis, purification, and handling of hazardous gaseous samples. • The design and development of new laboratory capabilities including gas manifolds, photolysis and electron sources and mass spectrometry analytical platforms. • Carrying out the optimisation and performing maintenance of synthesis lines, high vacuum equipment and cryogenic systems. • Performing data analysis including vibrational spectroscopy, mass spectrometry, X-ray and neutron diffraction crystallography, as well as performing supporting DFT calculations. • Contributing toward novel experiment design. • Liaising with the international team to coordinate remote experiments. • Preparing work for conference presentation, publication and assisting with the writing of manuscripts. • Undertaking any relevant health and safety training to ensure sound health and safety practices are carried out. Kā pūkeka me kā wheako/Your skills and experience Successful candidates will have: • A PhD degree. • Previous experience with synthesis and purification of gas samples, including knowledge of safe handling and disposal procedures. • Previous experience with laboratory high vacuum and cryogenic systems as applied to astrochemistry or surface science studies. • Previous experience with powder x-ray and/or neutron diffraction and associated data analysis routines advantageous. Pūroko/Further details This is a fixed term (2.5 years), full- time position. We offer competitive salary, five weeks' annual leave, a 6.75% superannuation scheme, and the ability to achieve real work/life balance. More information regarding employee benefits can be found at: Employee Benefits. Applications from candidates with Māori and Pacific backgrounds or strong competencies in these areas are warmly encouraged. You must have the right to live and work in New Zealand to apply for this position, For further information, please contact Dr Courtney Ennis, via the contact details below. Tono/Application To submit your application (including CV and cover letter) please click the apply button below. Applications quoting reference number 2200570 will close on Monday, 2 May 2022.

英国剑桥大学博士后职位招聘 英国剑桥大学博士后职位—自动显微镜 Research Assistant/Associate in Automated Microscopy University of Cambridge Description A position exists for a postdoctoral Research Assistant/Associate to work on the development of novel high-throughput automated microscopy techniques for nanomaterial characterisation and device development. The role holder will join the Low-Dimensional Electronics Group under the supervision of Dr Jack Alexander-Webber. The successful individual will join a project that aims to develop new high- throughput automated microscopy, analysis and device integration techniques to generate large multi-technique characterisation datasets of nanomaterials, such as semiconductor nanowires, graphene, two-dimensional semiconductors. The post holder will be located in West Cambridge, Cambridgeshire, UK. The key responsibilities and duties are: ·  Designing, building and optimising a multi-technique microscopy/characterisation system. This could include a combination of brightfield/darkfield microscopy, photoluminescence/Raman spectroscopy, photocurrent mapping etc. ·  Programming hardware control and user interfaces for data capture, large- area substrate mapping, and automation based on real-time microscopy image feature detection. ·  Characterising nanomaterials based on these techniques, generating and analysing multi-technique datasets. ·  Writing and publishing journal papers on experimental findings. ·  Playing an active role in the day-to-day supervision of students involved in the project. ·  Working cooperatively within a team of academics, researchers and postgraduate students at Cambridge, and collaborating with industrial partners and other UK-based and international universities. The skills, qualifications and experience required to perform the role are: ·  A PhD in Materials Science, Electronic Engineering, Physics, Chemistry or Nanotechnology. ·  Track record of authoring high quality academic publications in field of microscopy, semiconductors/materials characterisation, or optical system development. ·  Experience and skills designing, building and optimising optical, material characterisation, or microscopy systems. ·  Interpersonal and leadership skills as required for interdisciplinary collaborative research project. ·  Motivation and enthusiasm for curiosity-driven research. Appointment at Research Associate level is dependent on having a PhD. Those who have submitted but not yet received their PhD will be appointed at Research Assistant level, which will be amended to Research Associate once the PhD has been awarded. Salary Ranges: Research Assistant:£27,116 - £31,406 Research Associate: £33,309 - £40,927 Fixed-term: The funds for this post are available for 5 months in the first instance, with a possibility of extension subject to available funding. Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online. Please ensure that you upload your Curriculum Vitae (CV), a covering letter, research publication list and the names and contact details of two referees in the Upload section of the online application. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application. Please submit your application by midnight on the closing date. If you have any questions about this vacancy or the application process, please contact Dr Jack Alexander-Webber (jaa59@cam.ac.uk) for queries of a technical nature related to the role and Sue Murkett (sm330@cam.ac.uk) for queries related to the application process. Please quote reference NM30619 on your application and in any correspondence about this vacancy.

英国牛津大学博士后职位招聘 英国牛津大学博士后职位—纳米光子学 Postdoctoral Research Assistant University of Oxford Department of Physics, Clarendon Laboratory Description The post is available initially for a fixed-term duration of 3 years with the possibility of extending to 5 years depending on pace of progress and publication record (subject to funding). The postdoc will work on a project aiming to develop sensitive single molecule optical experiments capable of operating down to the single-photon level. The project will aim to perform spectroscopy on single biomolecules (natural and artificially engineered) to study the phenomena arising from light-matter interaction in biosystems, including measuring non-classical correlations in the optical signals using a Hanbury Brown Twiss set-up and conformational changes in single-molecules. Prior experience of optics techniques and of developing optical setups, such as SERS, FLIM, FRET, SMLM, would be advantageous. The candidate will collaborate with different groups within the Condensed Matter Physics and Biophysics sub-departments and will be supported by teams with expertise in single-molecule optical biophysics techniques and quantum optics. The post holder will have the opportunity to teach. Essential 1. Applicants should possess or be close to obtaining a PhD in physics, materials, chemistry, nanoscience, biophotonics, nanophotonics, fluorescence imaging, or a related discipline 2. Proficient in using and assembling custom optical setups rather than commercial plug-and-play systems 3. Knowledge of fundamental biophysics principles and keenness to learn 4. Experience working with single molecule fluorescence probes, such as fluorescent proteins or organic dyes, or fluorescent nanoparticles 5. Solid knowledge of techniques such as Surface Enhanced Raman Spectroscopy (SERS), SMLM, FLIM, and FRET Holbein, J. et al, 2010 Phys. Biol. 7 031001. Previous experience applying these techniques to single-molecules are an advantage. 6. Evidence of relevant publications and ability to direct research independently 7. Willingness to work collaboratively, openly, to participate actively in group discussions, and to support and nurture junior group members Desirable 1. Experience working with self-labelling proteins such as Halo-tags or SNAP- tags 2. Experience with time-resolved spectroscopy 3. Experience with handling cryogens and work at low temperatures 4. Experience with laboratory software, such as LabVIEW Please direct enquiries about the role to Dr Tristan Farrow Tristan.farrow@physics.ox.ac.uk Only applications received before midday (UK time) 16 May 2022 can be considered. You will be required to upload a statement of research interests, CV and details of two referees as part of your online application. Contact Person : HR Team Vacancy ID : 156111 Contact Phone : Closing Date & Time : 16-May-2022 12:00 Pay Scale : STANDARD GRADE 7 Contact Email : recruitment@physics.ox.ac.uk Salary (£) : Grade 7: £33,309 – £40,927 pa

英国牛津大学博士后职位招聘 英国牛津大学博士后职位---分子生物学 Postdoctoral Research Associate. University of Oxford Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences Description We are looking for a Postdoctoral Research Associate to contribute substantially to the laboratory and computational research of the Ancestrally Diverse Musculoskeletal Atlas based at the Botnar Research Centre, University of Oxford. This is a partnership with the Human Cell Atlas and Chan Zuckerberg Initiative. This ground-breaking consortium works across 7 international sites and utilises next generation sequencing to generate a map of healthy muscle, tendon and bone including ancestrally diverse samples from countries including Zimbabwe, The Gambia, India, Turkey, Oman and Argentina. As postdoctoral research associate you will process human musculoskeletal samples for single nuclei RNA-seq and imaging validation. You will adapt, optimise, and compare existing next generation sequencing and imaging methods. You will help to analyse sequencing data using computational pipelines. You will also collaborate in the preparation of scientific reports and journal articles, present papers and posters and manage your own academic research and administrative activities. This involves small scale project management, to co-ordinate multiple aspects of work to meet deadlines. You will hold a PhD or equivalent in a medical or biologically related discipline (or near completion) and have strong laboratory expertise in molecular biology (including gene expression analysis) and methodology development. Experience of programming in high level scripting languages (preferably R) and proven understanding and experience in the fields of genomics, data processing and/or high-throughput data analysis is also essential. Experience with histology, cryo-sectioning and fluorescent imaging, and willingness to take on supervision responsibilities for undergraduate project students is desirable. This is a full time, fixed-term appointment for 3 years. The closing date for this position is 12 noon on Friday 22 April 2022. You will be required to upload a supporting statement as part of your online application. Contact Person : NDORMS HR Vacancy ID : 156999 Contact Phone : Closing Date & Time : 22-Apr-2022 12:00 Pay Scale : STANDARD GRADE 7 Contact Email : hr@ndorms.ox.ac.uk Salary (£) : Grade 7: £33,309 - £37,467 p.a.

英国牛津大学博士后职位招聘 英国牛津大学博士后职位---传染病的病毒学和免疫学 Senior Postdoctoral Scientist-RADAR University of Oxford Description Applications are invited for a Senior Postdoctoral Scientist to join the Pandemic Sciences Institute, Nuffield Department of Medicine. In this position you will undertake an office-based knowledge gathering exercise for the RADAR project (Resources and Data to support a rapid Response to Pandemic Threats) which will underpin the work of multiple groups in the Pandemic Sciences Institute. This work will involve performing a gap analysis of knowledge and resources required for the development of vaccines, diagnostics and therapeutics for priority pathogen virus groups. You will synthesise highly technical information from all relevant disciplines into detailed technical reports on relevant research landscape of the priority pathogen virus groups, and be involved in interorganisational liaison and network building for collaborative work on gap identification and remediation. It is essential that you hold a PhD in a relevant biological sciences subject, and have a strong background in virology and immunology of infectious diseases, demonstrated by a first author publication in a high impact multidisciplinary scientific journal. You will have practical experience with at least one of the following: recombinant protein production and characterisation, serology assays, assay validation, cellular immunity assays, preclinical vaccine assessment, and have the ability to interpret scientific data, analyse and research complex issues, and write factual reports with supporting information. You will be self-motivated and capable of working both independently and as a part of a group. It is essential that you have excellent communication skills, including the ability to present data and represent research objectives at meetings. Applications for this vacancy are to be made online and you will be required to upload a supporting statement and CV as part of your online application. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. This position is offered full time (part time hours also considered, minimum 50% FTE) on a fixed term contract for 2 years, and is funded by Donor Funds. Only applications received before 12 midday on Tuesday 19 April 2022 will be considered. Please quote 156633 on all correspondence. Contact Person : Kaitlin Beazley Vacancy ID : 156663 Contact Phone : 01865 287734 Closing Date & Time : 19-Apr-2022 12:00 Pay Scale : STANDARD GRADE 8 Contact Email : recruitment@ndm.ox.ac.uk Salary (£) : Grade 8: £42,149 - £50,296 with a discretionary range to £54,943 per annum

美国约翰霍普金斯大学正在招收访问学者、博士后 约翰斯·霍普金斯大学（Johns Hopkins University，简称:Hopkins或JHU）创立于1876年，是一所世界顶级的著名私立大学，美国第一所研究型大学，也是北美学术联盟美国大学协会（AAU）的14所创始校之一。美国国家科学基金会连续33年将该校列为全美科研经费开支最高的大学。 想要出国访问学习的小伙伴看过来啦，美国约翰霍普金斯大学细胞分子生物学、免疫学方向正在招收访问学者、博士后！51访学网小编每周定时更新最新的访学招聘信息，感谢关注51访学。 高度积极的研究人员或博士后/访问学者科学家将被邀请领导几个新项目，以解决蛋白质稳态的基本问题(Lu等人，PLoS Biology 2021;路等。自然神经科学2019)，RNA稳态(Zhang等人。 分子细胞2018;Haeusler et al。Nature 2014)，以及Wang等人，Cell metabolism (Cell metabolism, 2021)在jiuou Wang实验室进行的与神经退行性疾病相关的研究。招收生物化学、分子生物学、细胞生物学、结构生物学等相关专业背景的研究人员。特别鼓励有基因组和转录组生物信息学分析经验的学生申请。 约翰霍普金斯医疗机构为生物医学研究提供了一个刺激和协作的环境。我们的实验室隶属于彭博公共卫生学院生物化学和分子生物学系以及医学院神经科学系。巴尔的摩/华盛顿特区地区也提供了丰富的专业和生活机会。 具有博士学位和较强的研究背景。请将研究经历和职业目标陈述、个人简历及至少一份联系人联系方式发送至jiouw@jhmi.edu。 pubmed可访问的出版物的完整列表可以通过以下URL访问更多信息请访问:http://www.jhu-bmb-phd.org/faculty/jiou-wang。约翰霍普金斯大学是一个提供平等机会的雇主。

美国哥伦比亚大学欧文医学中心博士后职位招聘 美国哥伦比亚大学欧文医学中心博士后职位--病理学与细胞生物学方向 Columbia University Irving Medical Center The Department of Pathology and Cell Biology at Columbia University Irvine Medica Center seeks a highly qualified and motivated postdoctoral researcher within the Siegelin lab. The scientist will perform cutting-edge research in the setting of an interdisciplinary, interactive, and highly collaborative international recognized medical center. Genetic, proteomic, metabolic, imaging, as well as bioinformatics cores, are available. Candidates with experience in epigenetics, metabolism, cell death pathways, and related fields are encouraged to apply. At CUIMC, we stand together because diverse experiences, perspectives, and values enrich every dimension of our work. Join our team and see how your unique skills and experiences can create a real impact by changing lives. The CUMC Dept of Pathology and Cell Biology is a world-class group of investigators that is one of the top-ranked Pathology Departments in the country that provides a supportive and collegial environment with extensive opportunities for professional development and advancement to top tier careers in academia and industry. Its location on the Upper West Side of Manhattan enables access to the multiple sites of interest, culture, and lifestyle in New York City. Job Function: - Supervised research training supported by a faculty’s grant or an individual fellowship. - Design and conduct of experiments related to brain tumor research following established protocols and organization of data. - Being able to work efficiently in a research team. - Implementation and development of new or derivative research protocols. - Summarizing research and preparation for publication in relevant scientific journals as well as presentation at conferences. Lab Mission/Purpose: The Siegelin lab within the Department of Pathology and Cell Biology is hiring a postdoctoral research scientist to begin immediately. The lab has a significant translational research focus and investigates novel treatments for malignant brain tumors by interrogating tumor cell metabolism, the epigenome and cell death mechanisms. Recent publications by our group: 1. Nat Commun. 2021 Sep 1;12(1):5203. doi: 10.1038/s41467-021-25501-x. 2. J Clin Invest. 2020 Jul 1;130(7):3699-3716. doi: 10.1172/JCI129049. 3. Nat Commun. 2017 Oct 20;8(1):1067. doi: 10.1038/s41467-017-00984-9. https://www.pathology.columbia.edu/profile/markus-d-siegelin-md Minimum Skills Required: PhD Preferred Qualifications: Prior experience in cancer research. Application Instructions Interested candidates should submit their CV and the contact information of three professional references to the attention of Dr. Markus Siegelin through the Interfolio web link. Equal Employment Opportunity Statement Columbia University is an Equal Opportunity Employer / Disability / Veteran

美国贝勒医学院博士后职位招聘 美国贝勒医学院博士后职位--肿瘤生物学 Baylor College of Medicine Postdoctoral Associate - Cancer biology Summary A postdoctoral position is immediately available in Dr. Weei-Chin Lin’s lab at the Departments of Medicine (Hematology and Oncology) and Molecular and Cellular Biology, Baylor College of Medicine. The successful candidate will study novel mechanisms of drug resistance in cancer (PNAS, 2021, PMID 33408251) and investigate new synthetic lethal combinations of targeted therapies. Eligible candidate will be considered for enrollment into a NCI T32 training program to foster her/his scientific career development. Dr. Lin is a physician-scientist and Program Director of BCM Oncology T32  Training Program. Dr. Lin’s lab studies the regulation of cell cycle and DNA damage response with the goal of developing novel cancer therapeutics. Lin lab is a highly productive working environment. Other recent publications include: Cancer Lett., 2021, PMID 34400221; JBC 2021, PMID 33556369; PNAS 2020, PMID 32541040; Mol. Cell Biol., 2020, PMID 31964753; Breast Cancer Res., 2019, PMID 31801577. Interested candidates should email their CV, a cover letter explaining their  relevant work experience and 3 names of references to Dr. Weei-Chin Lin at weeichil@bcm.edu. Job Duties Under the direction of the Principal Investigator to perform the following duties: •Plans, directs and conducts research experiments. •Evaluates and analyzes data. •Documents results of experiments and reports to principal investigators. Minimum Qualifications •MD or Ph.D. in Basic Science, Health Science, or a related field. Preferred Qualifications •Highly motivated individuals with PhD in molecular and cell biology, with a demonstrated competence and experience and publications in internationally recognized journals. •Technical expertise in standard basic molecular and cellular techniques, including cell culture, transfections and molecular cloning is a necessity. •Experience with animal studies is preferred. •Candidates must be enthusiastic, self-motivated, dedicated to science and problem solving, with organizational skills and effective at working independently and leading projects, while also collaborating and assisting the team in its collective research goals. •Preference will be given for the candidates eligible for NIH training grants (US citizens or permanent residents). Other •We are seeking high-quality recent PhD graduates with strong motivation and determination for academic career. Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.

美国弗吉尼亚大学博士后职位招聘 美国弗吉尼亚大学博士后职位招聘--呼吸免疫学 University of Virginia Postdoctoral Research Associate A NIH-funded postdoctoral fellow position in Respiratory Immunology is available in Dr. Jie Sun’s laboratory in the Carter Immunology Center (CIC) at the University of Virginia (UVA). CIC is a nexus for basic and translational immunology research that bridges multiple Departments at the University of Virginia School of Medicine. The qualified candidate should have a Ph.D. or equivalent degree in Immunology, Virology, Lung Biology or a related field. Candidates are expected to have intensive experiences in small animal procedures, flow cytometry, molecular biology and immune cell purification and culture etc. Candidates with solid background in adaptive immune responses are particularly encouraged to apply. Strong time management and communication skills, and the ability to work both independently and as part of a team are required. Projects for the position will focus on the roles of tissue resident macrophage or lymphocytes in balancing host protection and tissue pathology following respiratory viral infections (Influenza, RSV and SARS-CoV2 infections). The laboratory pursues a multidisciplinary approach that includes immunology, virology and pulmonary biology. For more information on the scientific background, please see below websites and following papers: 1. Science Immunol. 2019 Jun 14;4(36). 2. Immunity. 2019 Sep 17;51(3):491-507.e7. 3. Science Immunol. 2020 Nov 6;5(53):eabc4557. 4. Science Immunol. 2021 Jan 8;6(55):eabb6852. 5.  Immunity. 2021 Jun 8;54(6):1200-1218.e9. 6. Science Immunol.2021 Nov 12;6(65):eabk1741. 7. Medrxiv. 2022.  2022. 01.26.22269659v1. https://research.med.virginia.edu/cic/faculty/?facbio=1&id=1539754 https://twitter.com/Jie_Immunology https://scholar.google.com/citations?user=DxiUsXUAAAAJ&hl=en Qualifications: Candidate is expected to have a Ph.D., M.D., or equivalent doctoral degree in a field relevant to the lab research program. Research Fellow is appropriate for individuals who have completed no more than one prior postdoctoral fellowship, at UVA or elsewhere. Please send the following information to Dr. Jie Sun (email: js6re@virginia.edu) at the time of application: 1. Current curriculum vitae and bibliography 2. Personal statement on research interests (2-3 pages) 3. Contact information on three references. Centrally located in Virginia, Charlottesville boasts a thriving intellectual community and cultural life, with easy access to recreational venues and convenient travel to Richmond and Washington D.C. For more information about UVA and the surrounding area, please visit https://hr.virginia.edu/careers-uva/why-charlottesville The University of Virginia, including the UVA Health System which represents the UVA Medical Center, Schools of Medicine and Nursing, UVA Physician’s Group and the Claude Moore Health Sciences Library, are fundamentally committed to the diversity of our faculty and staff. We believe diversity is excellence expressing itself through every person’s perspectives and lived experiences. We are equal opportunity and affirmative action employers. All qualified applicants will receive consideration for employment without regard to age, color, disability, gender identity or expression, marital status, national or ethnic origin, political affiliation, race, religion, sex (including pregnancy), sexual orientation, veteran status, and family medical or genetic information.

美国西奈山伊坎医学院博士后职位招聘 美国西奈山伊坎医学院博士后职位--医学基因组学 Icahn School of Medicine at Mount Sinai (ISMMS), MSHS Postdoctoral fellow in medical genomics We are looking for highly motivated, detail-oriented computational (dry) or experimental (wet) PhDs with genuine interested in research bridging medicine and genomics to join the Tsankov lab (www.tsankovlab.org) in NYC. Our lab’s overall vision is to build data-driven, quantitative models that improve diagnosis, find new drug-able pathways, and personalize treatment of patients with lung cancer and respiratory diseases. We use single cell technologies (cell transcriptomic, epigenomic, and spatial) on clinical samples in order to dissect the regulatory mechanisms that drive the development of lung disease and understand how interactions with the immune and stromal microenvironment can be targeted for personalized therapy. PhDs with experience in bioinformatics, genomics, genetic mouse modeling, organoid co-culturing, immunology, lung, and cancer biology are highly encouraged to apply. New lab members have the option of being cross-trained to apply and develop computational frameworks and experimental techniques for single-cell transcriptomic, epigenomic, and spatial data and will frequently interact with multi-disciplinary, clinical scientists at Mount Sinai and the Broad Institute. We value team oriented individuals with excellent written/verbal communication skills and ability to think creatively and work independently. Interested applicants please send 1) your CV with a list of publications and research experiences, 2) a short summary of your present and future research interests, and 3) list of three references and their contact information to alexander.tsankov@mssm.edu. Compensation exceeds the NIH pay scale and position includes subsidized housing.

瑞士诺华生物医学研究所(NIBR)创新博士后职位招聘 Novartis Institutes for BioMedical Research (NIBR) Novartis Innovation Postdoctoral Fellowship Are you a talented and passionate early-career scientist whose goal is to make innovative medicines? The Novartis Innovation Postdoctoral Fellowship offers aspiring drug hunters a unique opportunity to join our teams at the Novartis Institutes for BioMedical Research (NIBR), the innovation engine of Novartis. Mentored by experienced NIBR scientists, Innovation Fellows will gain first-hand experience in the design and development of breakthrough therapies and innovative technologies. We are looking for Innovation Fellows who will harness their scientific creativity and natural curiosity to help bring transformative treatments to patients. Join us as we reimagine medicine together. All applications will be evaluated by a review team comprised of NIBR discipline experts. Candidates selected as finalists will be invited for an all-day virtual interview in June 2022. New cohorts of Innovation Fellows are expected to start in September 2022 at our Basel or Cambridge, MA site. Program highlights •Program duration: 2-3 years •Mentorship & access to technology: Innovation Fellows will drive a multi-year research project under the mentorship of distinguished NIBR scientists and have access to NIBR state-of-the-art technology platforms to achieve their research goals •Curriculum: at the start of their Fellowship, Innovation Fellows will attend  a comprehensive training series (boot camp), including dedicated courses covering the fundamentals of drug discovery and development •Rotation option: toward the end of their Fellowship, Innovation Fellows will have the opportunity to choose a short-term rotation in either a scientific or business-related discipline to broaden their exposure and skillset •Fireside chats with local leading scientists and entrepreneurs •Community: Innovation Fellows will join our vibrant postdoctoral community for dedicated events, including the monthly postdoctoral seminars and our annual Research Day Symposium Diversity & Inclusion / EEO Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve. Qualifications •Early-career scientists (MD and/or PhD), with terminal degree received within the last 3 years (students graduating in the next 5 months are eligible to apply) •Dedicated to translating scientific discoveries into medicines that improve human health •All scientific and technical disciplines welcome (biology, chemical biology,  chemistry, computational and data sciences, and more) •Strong publication record or other scientific achievements (i.e. awards, patents) •Entrepreneurial mindset and boundless curiosity To apply for the Innovation Fellowship at either our Basel (CH) or Cambridge, MA (US) site, you must use the link to the application portal below. Please note that this on-line application process requires uploading a Curriculum Vitae (CV) and cover letter in a pdf file format. In the cover letter, please include a potential area of unmet medical need where you believe you could make an impact. Use this link: https://nibr-bei.smapply.io/ to select the relevant program and begin the application process. The application link will be active only during the open application periods: • Cambridge, MA Fellowships: February 24th to April 14th, 2022 • Basel Fellowships: March 2nd to April 21st, 2022 Applicants will receive an automated email notification that their application has been received. If you have any questions, please contact us at nibr.postdoc@novartis.com. Why Novartis? 769 million lives were touched by Novartis medicines in 2020, and while we’re proud of this, we know there is so much more we could do to help improve and extend people’s lives. We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working. We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what’s possible, when we collaborate with courage to aggressively and ambitiously tackle the world’s toughest medical challenges. Because the greatest risk in life, is the risk of never trying! Imagine what you could do here at Novartis!

美国范德堡大学访问学者、博士后职位招聘 范德堡大学（Vanderbilt University），简称Vandy，又名范德比尔特大学，创立于1873年，由美国铁路大亨科尼利尔斯·范德比尔特捐建，是位于美国田纳西州纳什维尔市的一所私立研究型大学，被誉为“新常春藤”。 ​想要出国访问学习的小伙伴看过来啦，范德堡大学免疫学和/或免疫疗法、化学、分子工程和生物材料方面或相关学科方向正在招收访问学者、博士后！51访学网小编每周定时更新最新的访学招聘信息，感谢关注51访学。 范德比尔特大学约翰·T·威尔逊教授实验室的多个博士后、访问学者研究职位正在寻找候选人。也鼓励对研究助理教授或职员科学家职位感兴趣的合格申请人申请。威尔逊实验室 ( www.wilsonlabvanderbilt.com ) 正在研究工程和免疫学的界面，以开创下一代免疫疗法。 目前的项目得到了几项多年期拨款的支持，这些拨款专注于开发用于癌症免疫疗法和传染病疫苗的分子工程疗法。 成功的申请者将有机会通过汇集化学、纳米技术、药物科学和免疫生物学方面的专业知识来引领新免疫治疗技术的发展。理想的候选人将具有以下两个领域之一的经验并满足以下资格： 免疫学和/或免疫疗法 博士 在免疫学或相关领域（分子/细胞生物学，癌症生物学，生物医学工程）。 需要在分子/细胞生物学/免疫学技术和实验设计方面拥有丰富的经验，包括小鼠模型中免疫反应的表征。 免疫学、免疫疗法或癌症生物学方面的出版物非常受欢迎。 化学、分子工程和生物材料 博士 在化学（例如，有机化学、药物化学、高分子化学）、工程（例如，化学、生物医学、材料科学与工程、分子）或相关领域。非常需要聚合物化学方面的专业知识。 在高分子化学、材料科学、生物材料、纳米医学、药物输送或相关学科有良好的发表记录。 需要有机合成、聚合物设计和合成、纳米颗粒合成/表征、生物共轭化学、蛋白质工程、核酸和/或肽合成方面的经验。 非常需要对生物材料和药物输送系统进行体外和体内评估的经验。 所有候选人都应： 展示出强大的口头和书面沟通能力，以及为研讨会、期刊出版物和赠款提交组织材料的能力。 能够在多学科、多样化和协作的研究环境中很好地工作。 积极主动地发表严谨和高影响力的作品。 对科学、创新和创造性思维怀有真正的感染力。 您将在免疫工程和免疫治疗的前沿和快速发展领域接受培训，并加入一个由化学家、工程师、免疫学家、癌症生物学家和转化科学家组成的有趣、充满活力和跨学科的多研究者研究团队。我们的实验室位于新的、最先进的工程和科学大楼 ( ESB) 我们是一个多元化、支持性和包容性的群体；我们非常关心我们的学员，并将他们的成功作为我们的首要任务，不受他们的背景、经验、偏好或信仰的影响。 您还将受益于紧凑且高度协作的范德比尔特校区提供的其他专业知识和资源，包括范德比尔特纳米科学与工程研究所、范德比尔特英格拉姆癌症中心、范德比尔特感染、免疫学和炎症研究所以及范德比尔特大学医疗中心，仅举几例。不同研究专业知识的紧密联系是范德比尔特跨学科和转化研究成功的有力贡献者，并将为您提供丰富的研究、资助和职业网络机会。 最后，范德比尔特位于田纳西州纳什维尔市，这是一座繁荣发展的城市，拥有主要的文化、专业和体育机构。纳什维尔，被誉为“音乐之城”美国，”不仅提供世界级的音乐场景，还提供一流的美食、啤酒厂、博物馆、户外活动和天气。 薪酬将等于或高于NIH博士后指导方针，并将包括范德比尔特大学提供的有竞争力的福利和退休计划。博士后研究人员将获得一份可续签的年度合同，预计完成 2-4 年的培训。鼓励在个人感兴趣的领域进行研究、申请助学金和研究金以及发展独立研究方向的灵活性。有兴趣的候选人应在一个PDF文件中组装一份申请，其中包括 i) 求职信， ii) 简历（包括完整的出版物列表）， iii) 三个参考的联系信息，以及 iv) 已发表或接受发表的两篇第一作者手稿。求职信应包括候选人的相关研究经验、研究兴趣、对该职位的目标和期望以及首选开始日期的描述。申请应通过电子邮件发送给 John T. Wilson 教授， 地址为john.t.wilson@vanderbilt.edu ，主题为“威尔逊实验室的博士后职位”。

MD安德森癌症中心博士后职位招聘 德州大学安德森癌症中心（University of Texas MD Anderson Cancer Center，UT MDA）是全球著名癌症研究和治疗机构，始建于1941年，属德克萨斯大学系统成员之一，是集合肿瘤临床诊断、综合治疗及基础医学研究于一体的大型专科医院。连续30年被《美国新闻与世界报道》评为“ 癌症护理最好的医院” ，“ 全美最佳癌症治疗医院”，每年治疗超10万人。 想要出国访问学习的小伙伴看过来啦，德州大学安德森癌症中心癌症生物学和表观遗传学方向正在招收博士后！51访学网小编每周定时更新最新的访学招聘信息，感谢关注51访学。 MD 安德森癌症中心 Margarida Santos 博士的实验室可立即获得癌症生物学和表观遗传学博士后奖学金。该研究将侧重于表观遗传学和癌症起始、进展和靶向中的DNA损伤反应 ( DDR ) 的交叉点。长期目标是了解在正常分化过程中表观遗传调控及其与DDR相互作用的机制，以及这些过程如何在人类疾病中被破坏，并利用这些信息制定具体和有效的治疗策略。 培训和研究活动将包括使用急性髓性白血病和弥漫性大 B 细胞淋巴瘤的遗传小鼠模型，以及人类细胞系和患者来源的样本。下一代测序，例如RNA -seq 和 ChIP-seq，以及CRISPR筛选将在其他分子生物学技术中进行。荧光/共聚焦显微镜和流式细胞仪也是研究计划的组成部分。 Santos 博士的实验室获得了众多著名奖项和强大的资金支持。欲了解更多信息，请访问https://faculty.mdanderson.org/profiles/margarida_albuquerquealmeidasantos.html 候选人必须是最近的博士学位。或医学博士/博士。毕业于生物化学、遗传学、免疫学、癌症生物学或类似领域。优秀的发表记录（仅考虑在高影响力期刊上发表过一篇或多篇第一作者论文的候选人），以及在小鼠模型、流式细胞术、病毒转导、哺乳动物细胞培养和下一代培养/表征方面的经验需要排序。需要有英文科学写作或拨款准备的经验。请在此处通过 Slate申请，并附上您的简历、出版物以及研究经验和兴趣声明。

美国普林斯顿大学访问学者、博士后职位招聘 普林斯顿大学（Princeton University），简称“普林斯顿”，创建于1746年，是美国大学协会的14个始创院校之一，也是著名的常春藤联盟成员，是世界顶尖私立研究型大学，常年位居U.S. News美国最佳大学排名第1位。 ​想要出国访问学习的小伙伴看过来啦，普林斯顿大学细胞生物学、小鼠遗传学和分子生物学方面或相关学科方向正在招收访问学者、博士后！51访学网小编每周定时更新最新的访学招聘信息，感谢关注51访学。 我们每个人的身体中都有生物计时器，称为生物钟。这些时钟与昼夜周期相协调，驱动生理过程和行为。最近的工作提供了证据，表明生物钟与昼夜周期协调调节免疫功能。然而，生物钟驱动免疫节律的潜在机制尚不明确。 布鲁克斯实验室试图机械地确定肠上皮屏障先天免疫功能的生物钟调节。作为第一道防线，肠上皮必须从饮食中获取营养，同时与被称为微生物群的庞大微生物群保持和谐。上皮特有的是专门的上皮细胞和免疫细胞类型，它们产生抗菌蛋白、增强上皮屏障并协调免疫反应。先天免疫的这些基本功能受一天中的时间调节。 布鲁克斯实验室正在寻找一名博士后、访问学者候选人或更高级的研究员来描述跨肠上皮屏障的时钟对宿主防御的影响。 成功的候选人将加入一个在细胞生物学、小鼠遗传学和分子生物学方面具有优势的高度协作小组。PI 致力于提供一个培育性的培训环境，并承认必须为个人量身定制指导。 理想的申请者将具有很高的积极性；拥有博士学位 程度; 具有以下一项或多项细胞生物学、分子生物学、生物化学、生物信息学、遗传学、免疫学和/或微生物学的研究经验；流利的英语语言和写作能力。 具有以下一项或多项经验者优先：流式细胞术、电子显微镜、生物信息学、显微镜或细菌遗传学。该任命为期一年，在令人满意的表现和资金可用性之前有可能续签。 强烈鼓励历史上在分子生物学中代表性不足的群体成员的申请。 要申请，请将求职信、简历和三封推荐信提交至：https ://www.princeton.edu/acad-positions/position/25401 申请的审查将于 5 月 1 日开始，并将持续到职位被填补为止。该职位受大学背景调查政策的约束。 也欢迎非正式询问：电子邮件jb6683@princeton.edu。 普林斯顿大学是机会均等/平权行动雇主，所有合格的申请人都将获得就业考虑，不考虑年龄、种族、肤色、宗教、性别、性取向、性别认同或表达、国籍、残疾状况、受保护的退伍军人身份、或任何其他受法律保护的特征。EEO是法律。

加拿大英属哥伦比亚大学博士后职位招聘 加拿大英属哥伦比亚大学博士后职位--肌痛性脑脊髓炎/慢性疲劳综合征 Postdoctoral Fellow in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Job Summary BC Women’s Hospital & Health Centre and Women’s Health Research Institute are seeking a Postdoctoral Fellow (PDF) in the Complex Chronic Diseases Program (CCP) led by Dr. Luis Nacul for a 1-year term with a possibility of extension subject to funding. The position will be physically located at BC Women’s Hospital Campus as part of Department of Family Practice, Faculty of Medicine at the University of British Columbia. Background: Complex chronic diseases (CCDs), such as Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) are long in duration and there are no blood or other tests that can confirm diagnosis. In spite of research advances, factors involved in causing these conditions are still not fully understood. However, most cases are triggered by infectious diseases, such as mononucleosis and COVID-19. Each person with a CCD will experience their disease in a unique way, with symptoms that may or may not exactly match the most common descriptions. The Complex Chronic Diseases Program (CCDP) at BC Women’s Hospital & Health Centre is a provincial referral centre that aims to provide comprehensive and evidence-based care to adults with complex chronic diseases, including Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), Fibromyalgia and Chronic Lyme Syndrome. The Program engages in clinical care, education/knowledge transfer, quality improvement and research. The goal is to provide compassionate, innovative and integrated, care that promotes healing and improves the quality of life for patients using an interdisciplinary approach. This includes an emphasis on patient preferences in assessment and treatment decisions. Through partnerships with health care organizations, providers and community groups, the CCDP aims to raise the community standard of assessment and care for people living with these diseases. Project Summary: Myalgic Encephalomyelitis /Chronic Fatigue Syndrome (ME/CFS) is believed to affect over 38,000 British Columbians and 400,000 Canadians. Currently, there is no accurate data on the health status of patients with ME/CFS from across Canada. Addressing questions on the accuracy of data on the health status of people with ME/CFS on a provincial and national basis can be accomplished by accessing currently available data on well characterized individuals obtained retrospectively and prospectively; such as those by the unique, existing population cohort established through the Canadian Partnership for Tomorrow’s Health (CanPath) (n>300,000), and more specifically the BC Generations Project (BCGP). The BC EP-ME Study: Establishing a Population-based Cohort of People with Myalgic Encephalomyelitis in British Columbia: Feasibility Study, led by Dr. Luis Nacul, aims to establish a population-based cohort to help propagate much-needed research developments pertaining to ME/CFS in BC. Using data from consenting participants with and without ME from the BCGP, this project will help inform the future creation of the first Canadian data registry of ME/CFS. Factors such as personal health history, physical measurements, and history of viral exposures will be compared between participants with and without ME/CFS to better understand disease risk factors. This project is part of a Pillar 2 initiative within the three pillar Interdisciplinary Canadian Collaborative Myalgic Encephalomyelitis (ICanCME) Research Network, a multi-year Canadian Institutes of Health Research funded Catalyst Grant. Pillar 2 activities include the establishment of a centralized national ME database – the Canadian ME National Cohort (CMENC) and data management through harmonization of existing databases. Pillar 2 activities will be accomplished through: •Informatics and support for data capture and harmonization of regional cohorts. •Selection and validation of ME/CFS common data elements. •Standardization of ME/CFS case entry criteria. •Establishing Population-based cohorts and Clinical cohorts. •Digital markers and other mappable ME-related clinical measures, including deep phenotyping and provocation studies. Work Performed: The fellow will take a leadership role in supporting the BC EP-ME study and related Pillar 2 activities within ICanCME. This role will include opportunities for collaboration on research projects and interdisciplinary professional development activities across the network and research group strategic initiatives and their respective core projects. This will include collaboration on the already established Complex Chronic Diseases Program Data Registry (CCDPR) and the Pillar 1 virology study, “The contribution of virus infection to ME: A comprehensive virology study using the BC Generations Project (BCGP) and the Canadian Partnership for Tomorrow Project (CPTP) cohort”. Specifically, the fellow will: •Oversee BC EP-ME project timelines, initiatives, and deliverables. •Support related ICanCME Pillar 1 and 2 activities. •Foster research collaborations across a national network of ME/CFS researchers, clinicians, patient partners, and health care decision makers. •Conduct data management and data analysis using statistical software. •Deliver clear and concise written and oral presentations of the data at internal and external meetings. •Prepare, write and contribute to preparation of manuscripts for publication. •Identify funding opportunities and if required write or assist with grant proposals. •Mentor and supervise junior trainees and students. Qualifications •Current PhD candidate, or have been awarded a PhD within the last 5 years, in epidemiology, public health or related medicine and health disciplines, or within 10 years of being awarded a M.D. or D.D.S. degree. •Previous research experience using quantitative methods. •Excellent written and verbal communication skills. •Previous experience with scientific and grant writing is an asset. •Experience with data management or statistical analyses. •Preference will be given to candidates with a proven track record in health-related research with a minimum of 2 publications. •The candidate should have a demonstrated ability to work independently and as part of a team within a highly interdisciplinary environment. •Previous work in ME/CFS or other complex chronic diseases is an asset. Supervision Received The fellow will be physically located at BC Women’s Hospital + Health Centre and the Women’s Health Research Institute in Vancouver, Canada under the supervision of Dr. Luis Nacul, combination of in-person and virtual work will be expected depending on PHSA policies and research needs.  The fellow will report directly to Dr. Luis Nacul and the Research Manager. How to apply Please email Carola Muñoz (Research Manager) at carola.munoz@cw.bc.ca with ‘CCDP PDF Application’ in the email subject line. Applications will be reviewed starting March 30, 2022 and will remain open until filled. Only shortlisted candidates will be contacted. Your application should include the following: •Curriculum Vitae •Written personal statement: professional plans, research interests, and training goals. •Three professional references •List of publications Salary will be commensurate with level of experience and subject to UBC regulations for stipends for postdoctoral fellows. To learn more about the Complex Chronic Diseases Program (CCDP), please visit: http://www.bcwomens.ca/our-services/specialized-services/complex-chronic-diseases-program#What—is—a—CCD? This posting is for the UBC Vancouver campus in British Columbia, Canada. Please refer to reference number NC-55856 during correspondence about this position. Equity and diversity are essential to academic excellence. An open and diverse community fosters the inclusion of voices that have been underrepresented or discouraged. We encourage applications from members of groups that have been marginalized on any grounds enumerated under the B.C. Human Rights Code, including sex, sexual orientation, gender identity or expression, racialization, disability, political belief, religion, marital or family status, age, and/or status as a First Nation, Metis, Inuit, or Indigenous person. About UBC The University of British Columbia is a global centre for research and teaching, consistently ranked among the top 20 public universities in the world. Since 1915, UBC’s entrepreneurial spirit has embraced innovation and challenged the status quo. UBC encourages its students, staff and faculty to challenge convention, lead discovery and explore new ways of learning. At UBC, bold thinking is given a place to develop into ideas that can change the world. Postdoctoral Fellows at UBC Vancouver UBC is home to over 900 postdocs spanning all faculties and units across two campuses and a variety of affiliated hospitals, research centres, and sites, providing unparalleled opportunities to learn, discover and contribute in one’s own way. UBC’s Postdoctoral Fellows Office (PDFO) is committed to supporting the lives and career aspirations of our Postdocs, with the goal of enriching their experience at UBC and preparing them for the future. In addition to providing support and advocacy for all postdocs, the PDFO is dedicated to providing professional development opportunities that foster the development of soft skills needed in today’s professional environments, helping them secure future careers in their chosen fields. About UBC’s Faculty of Medicine Every day across British Columbia, trainees and researchers at the UBC Faculty of Medicine are turning skills into jobs, investments into discoveries, and discoveries into solutions that are transforming health for everyone. The UBC Faculty of Medicine offers a diverse array of training opportunities including cutting-edge research experiences in the biosciences, globally recognized population health education, quality health professional training, as well as several certificate and online training options. The Faculty of Medicine is home to more than 1,700 graduate students housed in 23 graduate programs (14 of which offer doctoral research options). Year after year, research excellence in the Faculty of Medicine is supported by investment from funding sources here at home and around the globe, receiving approximately $1.6B in total research funding in the last five years.

瑞典于默奥大学博士后职位招聘 瑞典于默奥大学博士后职位---人工智能模型在肿瘤转移和联合治疗中的应用 Umeå University (UmU) Postdoc position (2-years) focused on Cancer Metastasis and Combinational Treatment using Artificial Intelligence Models The Department of Molecular Biology, Umeå University, seeks a postdoctoral scientist in studies of cancer metastasis and combinational treatment using AI models. The position is full-time for two years with access as soon as possible or by agreement. Deadline for application: 20 April 2022. Background and description of work tasks We will assist the computer scientists to develop an artificial intelligence predictive model based on genomic, epigenomic and proteomic data at single cell level to predict disease progression and design tailored treatment strategies. Work task: 1. To perform multiplex gene expression analysis by using clinical samples and individual cancer cells and immune cells. Investigate and compare large numbers of candidate genes related to KRAS, PI3K/AKT and PIP5K1α pathways in individual cells between the primary tumors and metastatic lesions. 2. Establish cell line-models, organoid and animal models for testing for targeted drug validation and characterization for metastatic cancer under EU-REVERT Consortium. 3. Establish and utilize xenograft mouse models that recapitulate growth of primary tumors and formation of distant metastasis Investigate the prognostic values of tumor-specific signatures in primary tumours and metastatic lesions in predictive of distant metastasis. 4. Apply Artificial Intelligence Predictive models to validate on the large data from clinical databases of various types of metastatic cancer which share similar oncogenic pathways and mutations, in particular, KRAS pathways. Publications from our group: 1. Larsson PF, Karlsson R, Sarwar M, et al., Persson JL. FcγRIIIa receptor interacts with androgen receptor and PIP5K1α to promote growth and metastasis of prostate cancer. Molecular Oncology 2021 Dec 21. doi: 10.1002/1878-0261.13166. Online ahead of print. 2. Semenas J, Wang TY, Syed Khaja SA, Mahmud AKMF, Simoulis A, Grundström T, Fällman M, Persson Targeted Inhibition of ERα Signaling and PIP5K1α/Akt Pathways in Castration-Resistant Prostate Cancer. Molecular Oncology 2021,15:968-986. 3. Sarwar M, Syed Khaja AS, Aleskandarany M, Karlsson R, Althobiti M, Ødum N, Mongan NP, Deizy N, Johnson H, Green A, Ellis I, Rakha E, Persson JL. Targeted suppression of triple-negative breast cancer using PIP5K1α inhibitor. Oncogene 2019, 38:375-389. 4. Johnson H, Guo J et al., Persson JL and Chen LW. Development and validation of a 25-Gene Panel urine test for prostate cancer diagnosis and potential treatment follow-up. BMC Medicine 2020, 18:376. 5. Miftakhova R, Hedblom A, et al., Persson JL. Cyclin A1 and P450 aromatase promote homing and growth of stem-like prostate cancer cells to bone marrow. Cancer Research 2016,76:2453-2464. 6. Semenas J, Hedblom A, Miftakhova RR, Sarwar M, Larsson R, Shcherbina L, Johansson ME, Härkönen P, Sterner O, Persson JL. The role of PI3K/AKT-related PIP5K1α and the discovery of its selective inhibitor for treatment of advanced prostate cancer. Proc Natl Acad Sci U S A. 2014; 111:E3689-98. IF= 10.4. Qualifications Candidates must hold a University degree equivalent to a European University PhD degree in cancer biology, cell biology, or patho-biology (or equivalent fields) and be very skilful in bioinformatics at the time of the recruitment. To be eligible, you should have completed your PhD degree a maximum of four years before the end of the application period, unless special circumstances such as parental leaves exist. The ideal candidate should have academic ambitions and independent research skills and critical thinking and leadership quality. The candidate should have a strong drive in research and teaching. Candidates must have documented theoretical and practical experience in broad areas including tumor biology, patho-biology, bioinformatics, biochemistry, animal models and fluorescence microscopy. Candidates must be fluent in spoken and written English. Because the project will be of collaborative nature, candidates need to be able to work productively not only independently, but also in a team. Excellent communication skills are required for interacting effectively with senior colleagues and peers, including colleagues from complementary research fields. Application To find details of what your application should include, and apply electronically through the online application system, please go to https://umu.varbi.com/en/?jobtoken=16919620dcb907de2d31dd0e12f6a37d8760385da (or use the button “Apply via Recruiter”). Application deadline: 20 April 2022. About us The Jenny Persson lab is specialized in Cancer, Artificial Intelligence in Oncology at the Department of Molecular Biology. Partnerships including EU_GlycoImaging, EU_ REVERT, University of Nottingham, Weill Cornell Medical Center, New York. You can find more information about us at https://www.umu.se/en/staff/jenny-persson/. The position is employed at The Faculty of Medicine, which consists of 13 departments, is responsible for medicine and clinical and preclinical research and education in more than 80 subjects. The artificial intelligence and digital health have been applied in many areas at the Faculty of Medicine. The Department of Molecular Biology (https://www.umu.se/en/department-of-molecular-biology/) provides an excellent multidisciplinary research environment and cross-faculty state-of-the-art imaging, metabolomics, genomics and bioinformatics facilities. At Umeå University, everything is nearby. Our cohesive campus environment makes it easy to meet, collaborate and exchange knowledge, which promotes a dynamic and open culture where we rejoice in each other’s successes. If you are interested in knowing about Umeå University as a workplace, read more at: https://www.umu.se/en/work-with-us/. Umeå University also offers a strong postdoc community with the Umeå Postdoc Society (UPS) which fosters networking amongst postdocs, organises social and career development events and works towards improving the postdoc experience at Umea campus. Check out their website: https://umeapostdocsociety.se/ and do not hesitate to get in contact with them early on! We welcome your application!

英国牛津大学招收博士后职位招聘 英国牛津大学招收博士后研究助理---免疫学和细胞生物学方向 Postdoctoral Research Assistant NUFFIELD DEPARTMENT OF ORTHOPAEDICS, RHEUMATOLOGY AND MUSCULOSKELETAL SCIENCES (NDORMS) Postdoctoral Research Assistant (156710) Grade 7: £33,309 – £40,927 per annum We are looking for a talented Postdoctoral Research Assistant who is passionate about advancing fundamental knowledge of how the immune system is organized and how it functions in health and disease to join the group of Dr Tal Arnon at the Kennedy Institute, to work within the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences at the University of Oxford. The type of questions that we aim to address include: 1) how do lymphocytes navigate to specialized niches in lymphoid and non-lymphoid tissues during steady state and in response to infection or vaccination, 2) how does this process control the differentiation and survival of these cells, 3) how do activated lymphocytes migrate to infected tissues, 4) how these events lead to the establishment of a durable immunity against infectious diseases. In particularly, we are interested to explore these types of questions in the context of infection with influenza virus, focusing on mechanisms that promote the development, survival and function of resident memory B cells in the lung, and in the context of infection with blood pathogens, which present a life threatening risk of systemic infection. To address these questions, we apply cutting-edge imaging techniques that allow us to directly study dynamic and tissue-specific events in real time, combined with genomic methods, to couple positional information with expression profiles and identify molecular pathways that regulate immune cell function. •You will take responsibility for the planning, execution and analysis of high-quality research, ensuring the validity and reliability of data at all times, maintain ongoing scientific discussion with the PI and keep up-to-date knowledge of relevant publications and submit publications to high quality refereed journals. You will present work progress regularly and actively participate in group meetings and departmental seminars, as well as contribute to the smooth running of the Group’s laboratories with other scientists, technicians and students. You must hold a relevant phD/Dphil in immunology or cell biology (or near completion) and have a very good publication record in high impact peer reviewed journals; at least one first author publication in a journal with an impact factor of 4 or above is required, preferentially in the field of immunology. You will have extensive prior experience in immunology, experience in in vivo work and perform effectively under pressure, execute complex and demanding experiments, demonstrate an excellent work ethics, and show willingness to work flexibly. Experience with advanced analysis of tissues by microscopy and cells by microscopy is desirable. This is a fixed-term, full time position for 3 years. Due to the nature of the research at the Kennedy Institute of Rheumatology, this job will require additional security pre-employment checks: •A satisfactory basic Disclosure and Barring Service check •University security screening (eg identity checks) The closing date for this position is 12 noon on 16th of April. You will be required to upload a CV and supporting statement as part of your online application. To apply for this role and for further details, including the job description and selection criteria, please click on the link below: https://my.corehr.com/pls/uoxrecruit/erq_jobspec_details_form.jobspec?p_id=156710

英国医学研究委员会（MRC）博士后职位招聘 英国医学研究委员会（MRC）博士后项目---代谢与细胞生长 Medical Research Council MRC Postdoctoral Research Scientist (Metabolism and Cell Growth) Choosing to come to work at the MRC (part of UKRI) means that you will have access to a host of benefits from competitive salary and final salary pension scheme, 40.5 days leave per year and access to employee shopping/travel discounts and salary sacrifice cycle to work scheme, plus the chance to put the MRC and UKRI on your CV in the future. A 3-year postdoctoral position is available in the Metabolism and Cell Growth group headed by Dr Susumu Hirabayashi (https://lms.mrc.ac.uk/research-group/metabolism-cell-growth/), at the MRC London Institute of Medical Sciences (LMS) based on the Hammersmith Hospital Campus of Imperial College London. The LMS has first class facilities and provides investigators with the opportunity to pursue innovative, multidisciplinary research within the excellence of Imperial College London. For more information, visit www.lms.mrc.ac.uk. The group uses the fruit fly Drosophila melanogaster as a model system to study the systemic interplay between whole-animal metabolism and tumour growth. Current research interests in the lab include exploration of the molecular link between diet-induced obesity, tumour growth, and cachexia-like peripheral organ wasting. Our studies are underpinned by multidisciplinary approaches combining fly genetics, imaging, molecular and protein biology approaches, and high-throughput sequencing. The successful candidate must hold a PhD in a relevant biomedical discipline and have a strong interest in metabolism and/or cancer biology. Extensive experience in fly genetics and molecular biology techniques are essential. The successful candidate should have excellent verbal and written communication skills, a strong work ethic, meticulous record keeping, and, in addition, develop and carry out his/her own line of research within the group’s areas of interest. This is an MRC Postdoctoral Research Scientist position providing training and development supporting post-doctoral scientists in early or changed career paths helping establish them as successful research scientists in their chosen field. The MRC is a unique working environment where our researchers are rewarded by world class innovation and collaboration opportunities that the MRC name brings. For full details of this post and to complete an online application, visit https://mrc.tal.net/vx/lang-en-GB/appcentre-1/candidate/postings/1886 and upload your CV, names and contacts of two scientific references along with a covering letter stating why you are applying for this role (providing evidence against the requirements of the job as per the job description and person specification). Please quote reference number LMS 1803 Applications which do not provide a cover letter will not be considered. Closing date: 10th April 2022 Final appointment will be subject to pre-employment screening *Salary quoted is inclusive of London weighting. Additional allowances comprise a £1,000 lump sum Settlement Allowance plus a yearly Training Allowance of £850 in the first year, paid in monthly instalments. The Training Allowance increases to £1,300 in year two, and £1,800 in the third year. This role qualifies for endorsement by UKRI for a UK Global Talent Visa, for which the successful applicant is likely to be eligible to apply. Immigration costs for applicant (100% visa and 100% Health Surcharge) and immediate dependents (100% visa and 50% health surcharge when applying with main applicant) can be reclaimed from LMS after taking up the post (terms and conditions apply).

德国慕尼黑大学(LMU)博士后职位招聘 德国慕尼黑大学(LMU)博士后职位---染色质、癌症与代谢 Postdoctoral Fellow in Chromatin, Cancer & Metabolism Ludwig Maximilians University of Munich (LMU) The epigenetics of metabolites Metabolites mediate essential cellular responses to the environment, ensuring our survival. Changes in metabolic pathways are also key to how tumors evolve and thrive. Metabolites are not just substrates for enzymes, but act as signaling molecules that can directly and indirectly dramatically influence gene activity. Our team has a world-leading record in pioneering the discovery of novel interactions between gene regulatory factors and cellular metabolites or their products and to translate these discoveries toward novel therapies. We discovered that metabolites act as allosteric regulators of chromatin structure in the context of DNA damage and have now identified human transcription factors that act as metabolite receptors. We characterize these novel types of health-relevant gene-metabolism crosstalk. We seek postdocs for two exciting frontline projects. First, we identified human transcriptional receptors for endogenous metabolites and characterized how they recognize and alter their structure upon metabolite binding. This knowledge enables drug discovery. We will develop small molecule regulators of transcription factor activity (this project is covered by an m4Award of the Bavarian Government). In a second project, we will take this paradigm further to target the activity of other important cancer-relevant transcription factors. Together, we will investigate at the biochemical, cell biological, structural and chemical level how the activity of these transcription factors is directly modulated by small molecules. Our new knowledge and expertise will allow us to address one of the biggest challenges in drug discovery, the targeting of transcription factors via small molecules, for the benefit of patients. Recent publications: •Guberovic et al. Nature Struct Mol. Biol, 2021. 10.1038/s41594-021-00692-5 •Valera-Alberni et al. Cell Reports, 2021. 10.1016/j.celrep.2021.109565 •Blessing et al. Molecular Cell, 2020. 10.1016/j.molcel.2020.10.009 •Murawska et al. Molecular Cell, 2020 10.1016/j.molcel.2019.11.016 •Singh et al. Molecular Cell, 2017 10.1016/j.molcel.2017.11.019 •Kistemaker et al. Angewandte Chemie, 2016 10.1002/anie.201604058 •Hondele et al. Nature, 2013 www.nature.com/articles/nature12242 Our group is located at the LMU Biomedical Center, a state-of-the-art research and teaching center that targets cellular plasticity in health and disease. Further info at: www.ladurnerlab.de. We are generously funded by grants from the EU, DFG, LMU and Bavarian Government. Excellent in-house core facilities ensure access to specialized equipment and leading expertise. We are integrated within a robust R&D environment for innovative research in gene expression, chromatin dynamics, epigenetics and chemical biology, including through the DFG-funded Collaborative Research Centers SFB1064 (www.sfb1064.med.uni-muenchen.de) and SFB1309 (www.sfb1309.de). Our outstanding campus includes local partnerships with the two Max Planck Institutes for Biochemistry and Neurobiology, the Helmholtz Center Munich, the LMU Faculty of Biology, LMU Faculty of Chemistry and one of Europe’s largest biotech hubs, including the IZB and our startup Eisbach Bio (www.eisbach.bio). Candidates should be motivated, curious, project-, task- and team-oriented, communicate well and enjoy working together on pioneering projects at the forefront of biomolecular recognition. Ideally, you have a background in oncology, gene expression, chromatin or metabolism, and this technical expertise: •Biochemistry and biophysical analysis of proteins, X-ray crystallography, cryo-EM •Chemical biology, synthesis, pharmacy, enzymology and drug discovery •Physiology and genetic models of metabolic disease, model organisms (Drosophila) The successful candidate will collaborate within our team and across our outstanding academic and biotech campus. The salary is based on the public scale TV-L E13. The employment is planned for 3 years and can be extended. Please send any questions and your motivation letter, CV and names of 3 referees (in one PDF) by email to: andreas.ladurner@med.lmu.de.

英国剑桥大学博士后职位招聘 英国剑桥大学博士后研究员－净化的流体力学 Postdoctoral Research Associate In The Fluid Mechanics Of Decontamination (Fixed Term) University Of Cambridge Description Postdoctoral Research Associate in the Fluid Mechanics of Decontamination (Fixed Term) We are seeking a postdoc with experience in both theoretical and experimental work involving the fluid mechanics of absorbent media to join our research team modelling the decontamination of absorbent material. The successful candidate will be based in the Department of Applied Mathematics and Theoretical Physics. The overarching project aims to provide mathematical models of decontamination processes and is funded by the Defence Science and Technology Laboratory (Dstl). The approach to mathematical modelling is multifaceted, with experiments playing an important role not only in motivating and inspiring the mathematical approaches, but also in providing the data sets against which the models can be validated. The principal focus of this position within the team relates to the work on  absorbent media. The successful candidate will have or be about to receive a PhD in mathematics, engineering or a closely related area, and have experience in theoretical fluid mechanics and in conducting laboratory experiments. Familiarity with absorption and swelling processes is highly desirable. Duties include: developing theory, running and analysing experiments, numerical simulation, developing and conducting individual and collaborative research objectives, and liaising with project sponsors. The role holder will be expected to plan and manage their own research and administration, with guidance if required. They must be able to communicate material of a technical nature and be able to build internal and external contacts. They may also be asked to assist in the supervision of student projects, the development of student research skills, provide instruction or plan/deliver seminars relating to the research area. Fixed-term: The funds for this post are available for 18 months (to 31 October 2023) in the first instance. Click the 'Apply' button below to register an account with our recruitment  system (if you have not already) and apply online. Informal inquiries can be made by contacting Prof. Stuart Dalziel (s.dalziel@damtp.cam.ac.uk). If you have any questions about the application process, please contact LE30575@maths.cam.ac.uk. Please indicate the contact details of two academic referees on the online  application form and upload a full curriculum vitae and a description of your recent research (not to exceed three pages). Please ensure that at least one of your referees is contactable at any time during the selection process. Your referees should be aware that they will be contacted by the Mathematics HR Office Administrator to request that they upload a reference for you to our Web Recruitment System, and that their prompt response will help the process. Interviews are to be held in person or via Zoom soon after the 11 April closing date with a view to starting on or soon after 1 May 2022. Please quote reference LE30575 on your application and in any correspondence about this vacancy. The University actively supports equality, diversity and inclusion and encourages applications from all sections of society. We particularly welcome applications from women and /or candidates from a BME background for this vacancy as they are currently under-represented at this level in our Department. The University has a responsibility to ensure that all employees are eligible  to live and work in the UK. Further information Further Particulars Department/Location Department of Applied Mathematics and Theoretical Physics Salary £33,309-£40,927 Reference LE30575 Category Research Published 18 March 2022 Closing date 11 April 2022

英国伦敦大学博士后研究员职位招聘 英国伦敦大学博士后研究员职位招聘--伯贝克学院英语系 Postdoctoral Research Associate For Written Worlds Birkbeck, University Of London Description Postdoctoral Research Associate for Written Worlds We are seeking the first postdoctoral research associate for our project on  seventeenth-century non-elite writings and writers. This is a fixed term 12 months post at 0.5FTE on the Leverhulme Trust funded project ‘Written Worlds in Seventeenth-Century England' based in the Department of English, Birkbeck University of London. Salary range £39,173 rising to £44,775 per annum (pro-rata) Contract type Fixed term Mode Part time Grade　7 Business Unit (dept) Department of English, Theatre & Creative Writing Closing date for applicants 22-Apr-2022 Ref No 1161We are seeking the first postdoctoral research associate for our project on seventeenth-century non-elite writings and writers. This is a fixed term 12 months post at 0.5FTE on the Leverhulme Trust funded project ‘Written Worlds in Seventeenth-Century England' based in the Department of English, Birkbeck University of London. You will undertake dedicated research on a Leverhulme Trust funded large project grant, researching and writing on non-elite writing in seventeenth- century England. You will have the opportunity to work in archives, develop the project database and work on developing your own academic writing in an individual paper. Working closely with Principal Investigator (PI) Sue Wiseman (Dept of English Theatre and Creative Writing, Birkbeck) and Co-Investigator (CI) Brodie Waddell (Dept of History, Classics and Archaeology) you will lay the foundations of four interlocking packages for research: non-elite writing generated in the provinces; in and in relation to London; by women; and in relation to travel and encounter. This involves investigating datasets and working in archives. You will help the PI and CI to establish a database, working to build entries, establish formats and keep records. You will work with the PI and CI to join literary and historical methods in approaching the material and reflect on methodologies. Working primarily with the PI you will help to prepare a colloquium and potentially liaise with participants. Finally, you will develop a research paper on non-elite writing to deliver verbally and work towards shaping for publication. After the first year you will have the opportunity to apply for one of the four Research Associate posts (fixed term, 34 months) specialising in work on non-elite writing in the areas of Provinces, Women, London and Travel and Encounter, and to continue working with the project research, building the database, working towards publication goals, and potentially editing text. You have opportunity to work with staff in the Department of English, Theatre and Creative Writing in the School of Arts, which will be your base department, and with staff in the Department of History, Classics and Archaeology which will be your second home. You will also have the opportunity to participate in our Centre for Medieval and Early Modern Worlds and in the London Renaissance Seminar as well as be able to participate in Arts Week, the School's annual short festival. This is a half-time post and we will work with the postholder to ensure a balance between work on the database and research packages, the archives and analytical writing in order to establish a clear and viable work pattern. You should have a good first degree (probably in English Literature, History or a related area); have completed a PhD in a relevant subject area (which will most likely be English or History); and have a record of academic publication supported by robust plans for present and future research. You will need a basic ability to work with a database; have basic ability to research in English language manuscript and print primary materials 1600-1730; and you should be willing to build on and improve those skills and to put together historical and literary methods. Remuneration: Grade 7 of the College Salary Scale which is £39,173 rising to £44,775 per annum. The salary quoted will be for 12 months pro rata and is on the College's London Pay Scale which includes a consolidated Weighting/Allowance which applies only to staff whose normal contractual place of work is in the London area. Enquiries: If you would like to know more about the role please click on apply below or contact Professor Susan Wiseman on s.wiseman@bbk.ac.uk. If you have technical issues or difficulties using the recruitment portal please contact jobs@bbk.ac.uk, providing your name and the job reference number of the position. While we are happy to respond to all informal enquiries, only formal applications through the online system will be considered. Birkbeck offers a competitive salary and pension scheme, 31 days paid leave, flexible working arrangements and some of the most generous benefits in the HE sector, all while being located right in the heart of Central London. We welcome applicants from all sections of the community. The College is  committed to improving the gender and cultural diversity of its workforce,  holding an Athena SWAN award, membership of WISE, operating Disability Confident & Mindful Employer schemes.

美国佐治亚大学博士后职位招聘 美国佐治亚大学博士后职位--植物基因组学 Postdoctoral Associate - Wallace Lab University Of Georgia Description Posting Details Position Details Posting Number G/R16518P Working Title Postdoctoral Associate - Wallace Lab Department CAES-Applied Genetic Tech Ctr About the University of Georgia The University of Georgia (UGA), a land-grant and sea-grant university with statewide commitments and responsibilities, is the state's oldest, most comprehensive, and most diversified institution of higher education (https: // www. uga.edu/). UGA is currently ranked among the top 15 public universities in U.S. News & World Report. The University's main campus is located in Athens, approximately 65 miles northeast of Atlanta, with extended campuses in Atlanta, Griffin, Gwinnett, and Tifton. UGA was founded in 1785 by the Georgia General Assembly as the first state-chartered University in the country. UGA employs approximately 1,800 full-time instructional faculty and more than 7,700 full-time staff. The University's enrollment exceeds 39,000 students including over 30,000 undergraduates and over 9,000 graduate and professional students. Academic programs reside in 18 schools and colleges, as well as a medical  partnership with Augusta University housed on the UGA Health Sciences Campus in Athens. About the College/Unit/Department College/Unit/Department website Employment Type Employee Additional Schedule Information M-F, 8-5 Advertised Salary Anticipated Start Date 04/01/2022 Posting Date 03/03/2022 Closing Date Open Until Filled Yes Special Instructions to Applicants Location of Vacancy Athens Area EOO Statement The University of Georgia is an Equal Opportunity/Affirmative Action employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, ethnicity, age, genetic information, disability, gender identity, sexual orientation or protected veteran status. Persons needing accommodations or assistance with the accessibility of materials related to this search are encouraged to contact Central HR (hrweb@uga.edu). UGA Statement PLEASE NOTE: On December 7, 2021, the federal District Court for the Southern District of Georgia issued a preliminary injunction against enforcing the vaccine requirement for Federal Contractors pending further review. As a result, the requirements of the Executive Order and associated guidance, including the vaccination requirement for covered contractor employees, are currently not in effect. The University of Georgia is a Federal Contractor as defined by Presidential Executive Order 14042 and subject to the requirement that Federal Contractors must ensure that all covered employees, including those working remotely, are fully vaccinated by January 4, 2022. You may be required to show proof of your fully vaccinated status at the time of your start date, or have received a medical or religious exemption from the fully vaccinated requirement at the time of your start date. For more information regarding the Federal Contractor fully vaccinated employment requirement please visit https: // coronavirus.uga.edu/executive-order/ or call (706) 542-2222. Duties/Responsibilities Please approximate the percentage of time spent on each task (out of 100%) during a typical work week. List these tasks in order of importance, with the most critical task coming first. Do not list more than 6 entries – do not go below 5% time per assigned duty. Duties/Responsibilities Genetic mapping and analysis of maize brace root traits Percentage of time 45 Duties/Responsibilities Performing genomic analysis of conserved noncoding elements Percentage of time 35 Duties/Responsibilities Preparing presentations and manuscripts of results Percentage of time 15 Duties/Responsibilities Mentoring students in research Percentage of time 5 Position Details Position Information Minimum Qualifications should list both the minimum degree and the field which the degree must be earned. If prior work experience is required, the posting should list both the job in which the experience must be gained, and the minimum duration that will be accepted. Classification Title Post-Doctoral Associate AD FLSA Exempt UGA Job Code Job Family FTE 1.0 Minimum Qualifications Position Summary The Postdoctoral Research Associate in the Wallace lab will be responsible  for analyzing conserved noncoding elements in angiosperm genomes and for conducting genetic mapping of traits related to maize brace roots. The Postdoctoral Associate will also oversee undergraduate students who will maintain and phenotype the maize plants in question. This person will also help mentor new graduate students for which their supervision is essential for the proper execution of research. Relevant/Preferred Education, Experience, Licensure, Certification in Position Ph.D. in genetics, genomics, bioinformatics or related field. A research background in the plant sciences, genomics, and/or quantitative genetics is preferred, with a publication record showing productivity. Demonstrated leadership in research desired. Knowledge, Skills, Abilities and/or Competencies Advanced knowledge of genomics, bioinformatics, and genetic mapping /quantitative genetics is preferred. Demonstrated ability to communicate and demonstrate in-depth knowledge of the subject matter. Demonstrated critical assessment skills essential. Strong interpersonal and teamwork skills. Physical Demands Extended periods of sitting at a computer. Working outside during the summer for several hours at a time. Is this a Position of Trust? Yes Does this position have operation, access, or control of financial resources? No Does this position require a P-Card? No Is having a P-Card an essential function of this position? No Is driving a requirement of this position? No Does this position have direct interaction or care of children under the age of 18 or direct patient care? No Does this position have Security Access (e.g., public safety, IT security, personnel records, patient records, or access to chemicals and medications) Yes Contact Information Recruitment Contact Contact Details For questions concerning this position or recruitment progression, please refer to the Recruitment Contact listed below. Recruitment Contact Name Niki Walden Recruitment Contact Email nikiwalden@uga.edu Recruitment Contact Phone Posting Specific Questions Required fields are indicated with an asterisk (). Applicant Documents Required Documents Resume/CV Optional Documents Cover Letter

法国马赛癌症研究中心博士后招聘－胰腺癌个性化医疗 3-Year Postdoctoral Position On Chemosensitivity Mapping Of The Cell Subpopulations In Pancreatic... Universities And Institutes Of France Description Organisation/Company: INSERM U1068 Research Field: Biological sciences Researcher Profile: First Stage Researcher (R1) Recognised Researcher (R2) Established Researcher (R3) Application Deadline: 01/06/2022 00:00 - Europe/Brussels Location: France › Marseille Type Of Contract: Temporary Job Status: Full-time Hours Per Week: 35 Offer Starting Date: 02/05/2022 A 3 year post-doctoral position dedicated to the development of personalized medicine for Pancreatic Cancer is available in the "Pancreatic Cancer" team of the Cancer Research Center of Marseille, under the supervision of Dr. Nelson Dusetti and Dr. Philippe Soubeyran. Pancreatic adenocarcinoma (PDAC) is one the most aggressive form of cancer and is becoming a serious health problem as its incidence increases constantly. The main cause of death in PDAC is recurrence due to innate or acquired chemoresistance. Despite relative efficacy of therapies, a majority of tumors progress despite continued treatment, strongly suggesting the presence of chemotherapeutic-resistant cells in the tumor prior to treatment or the ability of some tumor cells to acquire resistance induced by treatment. The project will aim at studying and understanding the role intra-tumor heterogeneity and of its evolution during treatments at the cellular level. This will allow us to predict drug sensitivity of the different cell populations constituting the tumor before the treatment thereby offering individualized and appropriate therapies to each patient, sparing from toxicity of inefficient treatments. To proceed, we will use single cell RNA sequencing combined with cell lineage tracking in order to highlight the different mechanisms that drive the acquisition of the chemo-resistant phenotype at the individual cellular level. We will use this knowledge to identify predictive signatures of sensitivity and/or future acquisition of chemo-resistance. This project is funded through the ARC (Association pour la Recherche sur le Cancer). The CRCM (Cancer Research Center of Marseille, https: // www. crcm- marseille.fr/en) comprises nearly 450 people in 19 teams and 18 technological platforms. Research at CRCM covers all areas of oncology, from the basic to the translational and clinical research. The candidate will have to identify molecular signatures and to validate them on independent cohorts of patients. This project will be accompanied by expert teams in the field of bioinformatics. The candidate post doc will also participate to the development of novel strategies involving single cell RNAseq methodologies (SPLiT-seq) to gain insight into implication of intra- tumoral heterogeneity in treatment resistance. Consequently, candidates should have experience in the analysis of RNA-seq data, including of raw sequencing process, as well as good general knowledge in statistics and machine learning (supervised and unsupervised). Mastery of R in the Linux environment is required as well as a solid mastery of handling large corpora of data. Experience in single cell analyzes would be appreciated. A CV with list of publications accompanied by a letter of motivation and 2  recommendation letters should be addressed to Nelson DUSETTI nelson.dusetti@inserm.fr and Philippe Soubeyran philippe.soubeyran@inserm.fr Contact Information Organisation/Company: INSERM U1068 Organisation Type: Public Research Institution Website: https:// crcm.marseille.inserm.fr/en/ Country: France City: Marseille Postal Code: 13009 Street: Campus de Luminy

美国南加州大学博士后职位招聘 美国南加州大学博士后研究员--分子生物学方向 Postdoctoral Scholar Research Associate University Of Southern California Description Postdoctoral Scholar Research Associate Apply Keck School of Medicine Los Angeles, California USC's KSOM and Department of Stem Cell Biology and Regenerative Medicine is seeking for Postdoctoral Scholar Research Associate to join Dr. UnmeshJadhav's lab at the Eli and Edythe Broad CIRM Center. If you are passionate about investigating fundamental gene control mechanisms, tissue development and regeneration, and application of cutting-edge computational approaches in biological research, we would like to hear from you. We are particularly interested in individuals from diverse areas of educational background and experience, such as basic sciences, engineering, and medicine. We are particularly interested in understanding how chromatin modulation is at the heart of gene expression control, establishing cellular identity, as well as cell plasticity. To study this, we employ innovative experimental, technological, and computational methods and use the mammalian intestine as a primary model system. You will have an opportunity to design, develop, and implement experimental protocols and lead collaborative projects. You can learn more about our research at: https: // jadhavlab.usc.edu/ Required Skills: • PhD in Biological Sciences or related fields • Experience working with mouse or other animal models is desirable • Strong background in molecular biology techniques • Ability to work independently and as part of a team • Strong verbal and written communication skills in English Contact Information: Interested applicants should apply through this job requisition and also email the following documents to ujadhav@usc.edu 1) Cover letter 2) Curriculum vitae, and 3) Contact information for 3-5 references Other Job Accountabilities: - Serves as a research trainee for the purpose of enhancing and developing research competencies. Participates in planning, designing and conducting highly technical and complex research projects under the direction of a supervisor. May or may not work independently. - Identifies, researches, compiles and evaluates data sources, background information and/or technology related to area of specialization. - Analyzes and evaluates research data utilizing computers and provides interpretations requiring significant knowledge of a specialized area of research. Searches literature, utilizing all available resources including electronic, regarding new methodology and designs experiments accordingly. - Contributes to the development of research documentation for publication and/or prepares technical reports, papers and/or records. - Operates and maintains sophisticated laboratory/scientific equipment. The Postdoctoral Scholar Research Associate serves as a research trainee for the purpose of enhancing and developing research competencies. Participates in planning, designing and conducting highly technical and complex research projects under the direction of a supervisor. May or may not work independently. Analyzes research data and provides interpretations. Contributes to the development of research documentation for publication and/or prepares technical reports, papers and/or records. (Temporary, fixed- term; one year and renewable on the recommendation of the faculty mentor and at the discretion of the dean. May be renewed up to a maximum of five years.) REQ20114357 Posted Date: 03/17/2022 - Thru date - 2022-07-31 Apply