Research Fellow in Proteostasis
Are you an ambitious researcher looking for your next challenge? Do you have an established background in C. elegans biology? Do you want to further your career in one of the UKs leading research intensive Universities?
We are looking for a highly motivated individual to work in collaboration with an interactive research team in the van Oosten-Hawle lab and the laboratory of Dr Michalis Barkoulas at Imperial College London. The van Oosten-Hawle lab uses the nematode C. elegans as a model system to investigate how proteostasis is maintained at the level of an entire organism throughout aging and neurodegenerative protein misfolding diseases.
Cell non-autonomous proteostasis is maintained via transcellular chaperone signalling that activates chaperone expression from one tissue to another. Using C. elegans we have identified signalling components of transcellular chaperone signalling (TCS) and the Research Fellow will investigate differences in the tissue-specific interactome of these components, define their functional basis in a cell-type specific manner and analyse the muscle- specific chromatin binding profile and transcriptome driven by a transcription factor involved in TCS.
For more information on the scientific background and Methodology, please see: Cell 153, 1366–1378 (2013); Cell Rep 23, 3905–3919 (2018); Curr Biol. 2018 Feb 19;28(4):640-648.e5. doi: 10.1016/j.cub.2018.01.029; J Vis Exp. 2020 May 16;(159). doi: 10.3791/61357.
You should have a PhD (or be close to completion) in Genetics, Cell Biology, Biochemistry or related discipline. You must be able to provide evidence of expertise in C. elegans genetics, molecular biology, fluorescence imaging and microinjection. Experience in the analysis of next generation sequencing data, statistical techniques and experience in proteomics would be an advantage.