The Bergom Laboratory at Washington University in the Division of Cancer Biology of the Department of Radiation Oncology is seeking research fellow with training in molecular biology and/or genetics and small animal work, preferably in the context of radiation biology and/or cardiovascular research.
The laboratory focuses on identifying the genetic basis for sensitivity to cardiac radiation, as well as the mechanisms of radiation-induced cardiovascular dysfunction. Another focus of the laboratory is to identify factors in the tumor microenvironment that alter radiation sensitivity in breast cancers.
The overall goal of the laboratory is to improve the therapeutic ratio of radiation therapy by increasing efficacy or radiation in the tumor, while minimizing side effects from radiation exposure to normal tissues, with a special emphasis on radiation-induced cardiac disease.
The position offers an excellent opportunity to conduct research in a supportive and stimulating environment, closely collaborating with biologists, clinicians and other scientists, within the Department and other Institutes across the campus, including the McDonnell Genome Institute and the Institute for Informatics., as well as the Preclinical Research Facility and the Mouse Cardiovascular Phenotyping Core.
Candidates are expected to use mouse and/or rat models of radiation-induced cardiac dysfunction and genetic models and pharmacologic approaches to identify new therapeutic targets to improve outcomes of patients who are exposed to cardiac radiation as part of their cancer treatment.
Models may also include tumor models examining whether changes in normal tissue radiation sensitivity alter the effectiveness of radiation therapy in tumors.
Techniques employed include next generation sequencing and novel small animal and tumor imaging techniques.
POSITION RESPONSIBILITIES INCLUDE:
Actively pursue research under the supervision of PI while developing skills for independent research.
Critically analyze and summarize scientific literature.
Develop research questions, design and conduct experiments, critically analyze data.
Communicate methods, data, and results in presentations and via manuscript writing.
Assist with grant preparation.
Doctoral degree in science.
Doctoral degree in biology, chemistry, biomedical engineering, or related fields
Experience in tumor biology and/or cardiovascular biology
Experience with preclinical and translational research involving animals
Highly motivated with excellent oral and written communication skills
Understanding of next-generation sequencing technologies
Familiarity with radiation biology is preferred, but not necessary
The Cancer Biology Division within the Department of Radiation Oncology consists of a core group of clinical, biology, physics and computational science investigators who use both archived and prospectively collected tumor samples and data on normal tissues to ask fundamental questions about radiotherapy efficacy and cancer biology.
There is a strong focus on the identification of biomarkers that can be used to risk-stratify cancer patients and to identify patients for targeted therapies.
Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status.