We are seeking highly motivated candidates （Visiting scholar）with interests in regenerative biology to join Dr. Huang’s laboratory at UCSF
The laboratory uses the heart as a model system to investigate organ development, regeneration and repair in adult zebrafish, neonatal and adult mice,
with an emphasis on the pathways that regulate resident stem cell activation and mature cell dedifferentiation/proliferation, and with innovative and integrated approaches
in single cell analysis, advanced imaging microscopy and genome manipulation technology.
1, Developing novel intravital imaging in live animals and tissue clearing techniques for high- resolution visualization of cellular behavior, activity and interaction during heart development, regeneration and injury repair.
2,Performing functional screens to induce adult mouse and human cardiomyocyte regeneration using both candidate gene and directed evolution approaches integrated with CRISPR/Cas9 genome manipulation technology.
3, Taking pharmacological and genetic approaches to uncover the unifying principle governing the decline of regenerative potentials in adult mammalian organs and appendages including the heart, digit/limb, skin, brain, and spinal cord.
4, Leveraging the power of phylogenetic screen to identify novel mammalian animal models with extraordinary tissue regenerative capacity.
5, Investigating human genetic mutations and underlying molecular mechanisms in rare heart diseases that may result in preservation of cardiac regenerative potential.
We invite candidates with a highly productive training record, strong research motivation, and extensive experience in any of but not limited to the following areas: (1) developmental and regenerative biology,
(2) heart physiology and cardiomyocyte biology,
(3) cell division, signaling, and bioinformatics data analysis. Successful candidate will work in a highly interdisciplinary research program that interfaces developmental and stem cell biology, regenerative medicine, and cardiovascular diseases.
To apply, interested candidates should submit a single PDF file including
1) a cover letter with a brief statement of research experience, interest, and career plan,
2) curriculum vitae, and
3) a list of three references to Dr. Huang (Guo.Huang@ucsf.edu).