A postdoctoral or a visiting scholar fellow position is open in the laboratory of Dr. Chen Yao in the Department of Immunology and the Kidney Cancer Program at the UT Southwestern Medical Center.
The long-term goal of Yao laboratory is to identify molecular and cellular targets that can be harnessed to enhance the efficacy of vaccines and immunotherapies against infectious diseases and cancer.
The Yao lab utilizes systems immunology approaches to identify key regulators of T-cell differentiation and function.
Ongoing projects in the laboratory include:
1) Identify novel molecular regulators of long-term antitumor T cell immunity;
2) Identify biomarkers predicting the clinical outcome of cancer immunotherapy;
3) Dissect the mechanisms involved in the T cell response to chronic viral infections.
Dr. Yao received her PhD degree from the University of Minnesota under the supervision of Daniel Kaplan. She completed her postdoctoral training in the laboratory led by John O’Shea at the National Institutes of Health. Dr. Yao is currently an assistant professor in the Department of Immunology and the Kidney Cancer Program at UT Southwestern Medical Center. Dr. Yao is an awardee of the NIAID New Innovators Awards (DP2) and the CPRIT First-Time, Tenure-Track Faculty Scholar Award.
Yao C*, Lou G, Sun HW, Zhu Z, Sun Y, Chen Z, Chauss D, Moseman EA, Cheng J, D’Antonio MA, Shi W, Shi J, Kometani K, Kurosaki T, Wherry EJ, Afzali B, Gattinoni L, Zhu Y, McGavern DB, O’Shea JJ, Schwartzberg PL, Wu T*. (2021) BACH2 Enforces the Transcriptional and Epigenetic Programs of Stem-Like CD8 T cells. Nature Immunology, (online). DOI:10.1038/s41590-021-00868-7 *corresponding authors.
Yao C, Sun HW, Lacey NE, Ji Y, Moseman EA, Shih HY, Heuston EF, Kirby M, Anderson S, Chen J, Khan O, Handon R, Reilley J, Fioravanti J, Hu J, Gossa S, Wherry EJ, Gattinoni L, McGavern DB, O'Shea JJ*, Schwartzberg PL*, Wu T*. Single-Cell RNA-Seq Reveals TOX as a Key Regulator of CD8+ T cell Persistence in Chronic Infection. Nature Immunology, 2019 Jul;20(7):890-901. PMID: 31209400
PhD degree in immunology, microbiology, cancer biology or relevant fields.
Comfortable working with mice and/or patient samples
Experience with mouse cancer model is preferred
Experience with bioinformatics and next-generation sequencing is preferred but not required
Candidates who meet the above criteria are welcome to send their CV, cover letter, and contact information of three referees to Dr. Chen Yao at Chen.Yao@UTSouthwestern.edu